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    FBXW2 F-box and WD repeat domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 26190, updated on 3-Dec-2024

    Summary

    Official Symbol
    FBXW2provided by HGNC
    Official Full Name
    F-box and WD repeat domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:13608
    See related
    Ensembl:ENSG00000119402 MIM:609071; AllianceGenome:HGNC:13608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Md6; FBW2; Fwd2
    Summary
    F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 8.4), thyroid (RPKM 8.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FBXW2 in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (120756974..120793416, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (132953124..132989576, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123519252..123555694, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20222 Neighboring gene NFE2L2 motif-containing MPRA enhancer 171 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:123455017-123455827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28893 Neighboring gene adenosylhomocysteinase pseudogene 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:123530344-123531012 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:123555395-123556025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28895 Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:123587005-123587204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:123595637-123596180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:123603211-123603712 Neighboring gene Sharpr-MPRA regulatory regions 2033 and 13781 Neighboring gene proteasome 26S subunit, non-ATPase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117371

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in proteolysis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    F-box/WD repeat-containing protein 2
    Names
    F-box and WD-40 domain protein 2
    F-box and WD-40 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001375888.1NP_001362817.1  F-box/WD repeat-containing protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL138836, AL161911
      Consensus CDS
      CCDS43872.1
      UniProtKB/Swiss-Prot
      B3KRL8, Q4VXH2, Q7Z4V6, Q8WV51, Q9HA09, Q9UKA3, Q9UKT8
      UniProtKB/TrEMBL
      B2RAW3
      Conserved Domains (3) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      cd00200
      Location:140447
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]
    2. NM_001375889.1NP_001362818.1  F-box/WD repeat-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL138836, AL161911
      Consensus CDS
      CCDS94471.1
      UniProtKB/TrEMBL
      B4DT60
      Conserved Domains (2) summary
      cd00200
      Location:11318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:2256
      7WD40; WD40 repeat [structural motif]
    3. NM_001375890.1NP_001362819.1  F-box/WD repeat-containing protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL138836, AL161911
      UniProtKB/TrEMBL
      B2RAW3
      Conserved Domains (3) summary
      smart00256
      Location:92126
      FBOX; A Receptor for Ubiquitination Targets
      cd00200
      Location:172479
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:183217
      7WD40; WD40 repeat [structural motif]
    4. NM_012164.4NP_036296.2  F-box/WD repeat-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_036296.2

      Status: REVIEWED

      Source sequence(s)
      AL138836, AL161911, BC110334, DA703966
      Consensus CDS
      CCDS43872.1
      UniProtKB/Swiss-Prot
      B3KRL8, Q4VXH2, Q7Z4V6, Q8WV51, Q9HA09, Q9UKA3, Q9UKT8
      UniProtKB/TrEMBL
      B2RAW3
      Related
      ENSP00000476369.1, ENST00000608872.6
      Conserved Domains (3) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      cd00200
      Location:140447
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      120756974..120793416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423218.1XP_047279174.1  F-box/WD repeat-containing protein 2 isoform X6

    2. XM_017014615.3XP_016870104.1  F-box/WD repeat-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      B2RAW3
      Conserved Domains (3) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:165200
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:162382
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006717049.4XP_006717112.1  F-box/WD repeat-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006717112.1

      UniProtKB/TrEMBL
      B2RAW3
      Conserved Domains (3) summary
      smart00256
      Location:92126
      FBOX; A Receptor for Ubiquitination Targets
      cd00200
      Location:172479
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:183217
      7WD40; WD40 repeat [structural motif]
    4. XM_047423217.1XP_047279173.1  F-box/WD repeat-containing protein 2 isoform X6

    5. XM_047423214.1XP_047279170.1  F-box/WD repeat-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      B4DT60
      Related
      ENSP00000508243.1, ENST00000684405.1
    6. XM_024447509.2XP_024303277.1  F-box/WD repeat-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      B2RAW3
      Conserved Domains (3) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:165200
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:162382
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. XM_006717051.3XP_006717114.1  F-box/WD repeat-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006717114.1

      UniProtKB/TrEMBL
      B2RAW3
      Conserved Domains (3) summary
      smart00256
      Location:92126
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:197232
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:194418
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    8. XM_047423215.1XP_047279171.1  F-box/WD repeat-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      B4DT60
    9. XM_047423213.1XP_047279169.1  F-box/WD repeat-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RAW3
    10. XM_047423216.1XP_047279172.1  F-box/WD repeat-containing protein 2 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      132953124..132989576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362715.1XP_054218690.1  F-box/WD repeat-containing protein 2 isoform X6

    2. XM_054362710.1XP_054218685.1  F-box/WD repeat-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      B2RAW3
    3. XM_054362707.1XP_054218682.1  F-box/WD repeat-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RAW3
    4. XM_054362714.1XP_054218689.1  F-box/WD repeat-containing protein 2 isoform X6

    5. XM_054362712.1XP_054218687.1  F-box/WD repeat-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      B4DT60
    6. XM_054362711.1XP_054218686.1  F-box/WD repeat-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      B2RAW3
    7. XM_054362709.1XP_054218684.1  F-box/WD repeat-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      B2RAW3
    8. XM_054362708.1XP_054218683.1  F-box/WD repeat-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RAW3
    9. XM_054362713.1XP_054218688.1  F-box/WD repeat-containing protein 2 isoform X5