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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_008394.1 RefSeqGene
- Range
-
4840..107614
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001131008.2 → NP_001124480.1 tyrosine-protein phosphatase non-receptor type 12 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus with an incomplete PTPc domain when compared to isoform 1.
- Source sequence(s)
-
AK303602, BC050008
- Consensus CDS
-
CCDS47619.1
- UniProtKB/TrEMBL
-
B4E105
- Related
- ENSP00000392429.2, ENST00000415482.6
- Conserved Domains (2) summary
-
- cd00047
Location:1 → 173
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- pfam00102
Location:1 → 173
- Y_phosphatase; Protein-tyrosine phosphatase
-
NM_001131009.2 → NP_001124481.1 tyrosine-protein phosphatase non-receptor type 12 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains a distinct 5' UTR, skips an internal exon, and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus with an incomplete PTPc domain when compared to isoform 1.
- Source sequence(s)
-
AK296764, AK303602, BC050008
- Consensus CDS
-
CCDS47620.1
- UniProtKB/TrEMBL
-
B4E105
- Related
- ENSP00000397991.2, ENST00000435495.6
- Conserved Domains (2) summary
-
- cd00047
Location:1 → 162
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- pfam00102
Location:1 → 162
- Y_phosphatase; Protein-tyrosine phosphatase
-
NM_002835.4 → NP_002826.3 tyrosine-protein phosphatase non-receptor type 12 isoform 1
See identical proteins and their annotated locations for NP_002826.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
AB209524, AC006451, BC050008, CN395133
- Consensus CDS
-
CCDS5592.1
- UniProtKB/Swiss-Prot
- A4D1C5, B4DKY2, E9PBR5, E9PEH9, Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4
- Related
- ENSP00000248594.6, ENST00000248594.11
- Conserved Domains (2) summary
-
- smart00194
Location:28 → 292
- PTPc; Protein tyrosine phosphatase, catalytic domain
- cd00047
Location:60 → 292
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000007.14 Reference GRCh38.p14 Primary Assembly
- Range
-
77537295..77640069
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_006716073.5 → XP_006716136.1 tyrosine-protein phosphatase non-receptor type 12 isoform X3
- Conserved Domains (2) summary
-
- smart00194
Location:28 → 260
- PTPc; Protein tyrosine phosphatase, catalytic domain
- cd00047
Location:60 → 260
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
-
XM_017012474.3 → XP_016867963.1 tyrosine-protein phosphatase non-receptor type 12 isoform X4
- UniProtKB/TrEMBL
-
B4E105
- Conserved Domains (2) summary
-
- cd00047
Location:11 → 177
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- pfam00102
Location:11 → 177
- Y_phosphatase; Protein-tyrosine phosphatase
-
XM_047420673.1 → XP_047276629.1 tyrosine-protein phosphatase non-receptor type 12 isoform X1
-
XM_047420674.1 → XP_047276630.1 tyrosine-protein phosphatase non-receptor type 12 isoform X2
-
XM_047420675.1 → XP_047276631.1 tyrosine-protein phosphatase non-receptor type 12 isoform X4
- UniProtKB/TrEMBL
-
B4E105
-
XM_047420676.1 → XP_047276632.1 tyrosine-protein phosphatase non-receptor type 12 isoform X5
- UniProtKB/TrEMBL
-
B4E105
-
XM_047420677.1 → XP_047276633.1 tyrosine-protein phosphatase non-receptor type 12 isoform X6
RNA
-
XR_007060120.1 RNA Sequence
Alternate T2T-CHM13v2.0
Genomic
-
NC_060931.1 Alternate T2T-CHM13v2.0
- Range
-
78789201..78891996
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054358732.1 → XP_054214707.1 tyrosine-protein phosphatase non-receptor type 12 isoform X3
-
XM_054358733.1 → XP_054214708.1 tyrosine-protein phosphatase non-receptor type 12 isoform X4
- UniProtKB/TrEMBL
-
B4E105
-
XM_054358730.1 → XP_054214705.1 tyrosine-protein phosphatase non-receptor type 12 isoform X1
-
XM_054358731.1 → XP_054214706.1 tyrosine-protein phosphatase non-receptor type 12 isoform X2
-
XM_054358734.1 → XP_054214709.1 tyrosine-protein phosphatase non-receptor type 12 isoform X4
- UniProtKB/TrEMBL
-
B4E105
-
XM_054358735.1 → XP_054214710.1 tyrosine-protein phosphatase non-receptor type 12 isoform X5
- UniProtKB/TrEMBL
-
B4E105
-
XM_054358736.1 → XP_054214711.1 tyrosine-protein phosphatase non-receptor type 12 isoform X6
RNA
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XR_008487716.1 RNA Sequence