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    HTN1 histatin 1 [ Homo sapiens (human) ]

    Gene ID: 3346, updated on 27-Nov-2024

    Summary

    Official Symbol
    HTN1provided by HGNC
    Official Full Name
    histatin 1provided by HGNC
    Primary source
    HGNC:HGNC:5283
    See related
    Ensembl:ENSG00000126550 MIM:142701; AllianceGenome:HGNC:5283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIS1; Hst1
    Summary
    This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014]
    Expression
    Restricted expression toward salivary gland (RPKM 17545.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HTN1 in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70050438..70058848)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73385299..73393709)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70916155..70924565)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene statherin Neighboring gene histatin 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:70928535-70929734 Neighboring gene casein alpha s2 like A, pseudogene Neighboring gene casein alpha s2 like B, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    histatin-1
    Names
    PPB
    histidine-rich protein 1
    post-PB protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368990.1NP_001355919.1  histatin-1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC063956
    2. NM_002159.4NP_002150.1  histatin-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_002150.1

      Status: REVIEWED

      Source sequence(s)
      AC063956
      Consensus CDS
      CCDS3534.1
      UniProtKB/Swiss-Prot
      P15515
      Related
      ENSP00000246896.3, ENST00000246896.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      70050438..70058848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047450192.1XP_047306148.1  histatin-1 isoform X1

      UniProtKB/Swiss-Prot
      P15515
      Related
      ENSP00000424501.1, ENST00000511674.5

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_013171801.1 Reference GRCh38.p14 PATCHES

      Range
      90574..98984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331874.1XP_054187849.1  histatin-1 isoform X1

      UniProtKB/Swiss-Prot
      P15515

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73385299..73393709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349913.1XP_054205888.1  histatin-1 isoform X1

      UniProtKB/Swiss-Prot
      P15515