U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 56886, updated on 3-Dec-2024

    Summary

    Official Symbol
    UGGT1provided by HGNC
    Official Full Name
    UDP-glucose glycoprotein glucosyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:15663
    See related
    Ensembl:ENSG00000136731 MIM:605897; AllianceGenome:HGNC:15663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UGT1; HUGT1; UGCGL1
    Summary
    UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.1), colon (RPKM 6.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See UGGT1 in Genome Data Viewer
    Location:
    2q14.3
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (128091200..128195677)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (128527394..128631631)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128848774..128953251)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene archaelysin family metallopeptidase 2 pseudogene Neighboring gene Sin3A associated protein 130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:128743539-128744039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16509 Neighboring gene SRM pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 10373 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:128944162-128945361 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:128960126-128960359 Neighboring gene dynein light chain Tctex-type 3 pseudogene 2 Neighboring gene RPL14 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 Env is identified to have a physical interaction with UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21763, FLJ23671, FLJ23796

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables UDP-glucose:glycoprotein glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables UDP-glucose:glycoprotein glucosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' post-translational protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in UDP-glucosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum mannose trimming TAS
    Traceable Author Statement
    more info
     
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum quality control compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    UDP-glucose:glycoprotein glucosyltransferase 1
    Names
    UDP--Glc:glycoprotein glucosyltransferase
    UDP-glucose ceramide glucosyltransferase-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020120.4NP_064505.1  UDP-glucose:glycoprotein glucosyltransferase 1 precursor

      See identical proteins and their annotated locations for NP_064505.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein.
      Source sequence(s)
      AC017079, AC108059, AF227905, AK025416, BC041098, DB226703
      Consensus CDS
      CCDS2154.1
      UniProtKB/Swiss-Prot
      Q53QP2, Q53SL3, Q8IW30, Q9H8I4, Q9NYU2
      UniProtKB/TrEMBL
      A8KAK1
      Related
      ENSP00000259253.6, ENST00000259253.11
      Conserved Domains (2) summary
      cd06432
      Location:12561503
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:451202
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

    RNA

    1. NR_027671.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, would render this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC017079, AC108059, AK025416, AK293066

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      128091200..128195677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712635.5XP_006712698.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      A8KAK1
      Conserved Domains (2) summary
      cd06432
      Location:12481495
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:451194
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    2. XM_006712634.4XP_006712697.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A8KAK1
      Conserved Domains (2) summary
      cd06432
      Location:12501497
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:391196
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    3. XM_047445121.1XP_047301077.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X4

      UniProtKB/TrEMBL
      A8KAK1
    4. XM_006712636.4XP_006712699.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X3

      UniProtKB/TrEMBL
      A8KAK1
      Conserved Domains (2) summary
      cd06432
      Location:12451492
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:341191
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    5. XM_047445122.1XP_047301078.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X5

      UniProtKB/TrEMBL
      A8KAK1
    6. XM_047445123.1XP_047301079.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X6

      UniProtKB/TrEMBL
      A8KAK1
    7. XM_047445124.1XP_047301080.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X7

      UniProtKB/TrEMBL
      A8KAK1
    8. XM_047445125.1XP_047301081.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X8

      UniProtKB/TrEMBL
      A8KAK1
    9. XM_017004509.2XP_016859998.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X9

    10. XM_017004510.2XP_016859999.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      128527394..128631631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343041.1XP_054199016.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X3

      UniProtKB/TrEMBL
      A8KAK1
    2. XM_054343039.1XP_054199014.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A8KAK1
    3. XM_054343042.1XP_054199017.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X4

      UniProtKB/TrEMBL
      A8KAK1
    4. XM_054343043.1XP_054199018.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X5

      UniProtKB/TrEMBL
      A8KAK1
    5. XM_054343045.1XP_054199020.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X7

      UniProtKB/TrEMBL
      A8KAK1
    6. XM_054343040.1XP_054199015.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      A8KAK1
    7. XM_054343044.1XP_054199019.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X6

      UniProtKB/TrEMBL
      A8KAK1
    8. XM_054343046.1XP_054199021.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X8

      UniProtKB/TrEMBL
      A8KAK1
    9. XM_054343047.1XP_054199022.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X9

    10. XM_054343048.1XP_054199023.1  UDP-glucose:glycoprotein glucosyltransferase 1 isoform X10

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025777.1: Suppressed sequence

      Description
      NM_001025777.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.