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    ZNF724 zinc finger protein 724 [ Homo sapiens (human) ]

    Gene ID: 440519, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF724provided by HGNC
    Official Full Name
    zinc finger protein 724provided by HGNC
    Primary source
    HGNC:HGNC:32460
    See related
    Ensembl:ENSG00000196081 AllianceGenome:HGNC:32460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF724P
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See ZNF724 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23221599..23250394, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23356434..23385220, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23404401..23433196, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 730 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene BCL2 interacting protein 3 pseudogene 37 Neighboring gene sorting nexin 6 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23343199-23343774 Neighboring gene MPRA-validated peak3415 silencer Neighboring gene BCL2 interacting protein 3 pseudogene 38 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10459 Neighboring gene importin 5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10461 Neighboring gene vomeronasal 1 receptor 90 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. Kawamura Y, et al. Ann Rheum Dis, 2019 Oct. PMID 31289104, Free PMC Article
    2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    3. Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis. Li H, et al. Cell Rep, 2022 Dec 20. PMID 36543142
    4. N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective. Jonckheere V, et al. Int J Mol Sci, 2021 Apr 1. PMID 33916271, Free PMC Article
    5. Human transcription factor protein interaction networks. Göös H, et al. Nat Commun, 2022 Feb 9. PMID 35140242, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 724

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355404.2 → NP_001342333.1  zinc finger protein 724 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092329
      Consensus CDS
      CCDS86737.1
      UniProtKB/Swiss-Prot
      A8MTY0, B4DVU0
      Related
      ENSP00000413411.2, ENST00000418100.6
      Conserved Domains (5) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:143 → 526
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:530 → 610
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:340 → 360
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:548 → 572
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001355405.2 → NP_001342334.1  zinc finger protein 724 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092329
      Conserved Domains (3) summary
      COG5048
      Location:79 → 462
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:276 → 296
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:484 → 508
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001355406.2 → NP_001342335.1  zinc finger protein 724 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC092329
      Conserved Domains (5) summary
      smart00349
      Location:2 → 58
      KRAB; krueppel associated box
      COG5048
      Location:137 → 520
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:524 → 604
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:542 → 566
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      23221599..23250394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451520.2 → XP_024307288.1  zinc finger protein 724 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:79 → 462
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:276 → 296
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:484 → 508
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      23356434..23385220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321048.1 → XP_054177023.1  zinc finger protein 724 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_005791.3: Suppressed sequence

      Description
      NG_005791.3: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MTY0.3 GenPept UniProtKB/Swiss-Prot:A8MTY0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials