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    ZNF85 zinc finger protein 85 [ Homo sapiens (human) ]

    Gene ID: 7639, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF85provided by HGNC
    Official Full Name
    zinc finger protein 85provided by HGNC
    Primary source
    HGNC:HGNC:13160
    See related
    Ensembl:ENSG00000105750 MIM:603899; AllianceGenome:HGNC:13160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPF4; HTF1
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 3.9), thyroid (RPKM 2.6) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF85 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (20923251..20950697)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21061743..21089195)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21106057..21133503)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene proline rich 21 pseudogene Neighboring gene proline rich 21 pseudogene Neighboring gene keratin 18 pseudogene 40 Neighboring gene uncharacterized LOC112268247

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    zinc finger protein 85
    Names
    zinc finger protein 85 (HPF4, HTF1)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256171.2NP_001243100.1  zinc finger protein 85 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC008739, BC036394, BC047646, BP199573, DC358791
      UniProtKB/TrEMBL
      Q49A12
      Conserved Domains (5) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:174588
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:514534
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:443
      KRAB; KRAB box
      pfam13465
      Location:582606
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001256172.2NP_001243101.1  zinc finger protein 85 isoform b

      See identical proteins and their annotated locations for NP_001243101.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 3, resulting in an isoform (b) that has a distinct C-terminus and is significantly shorter than isoform c.
      Source sequence(s)
      AC008739, BC068066, BM755583, BP199573
      Consensus CDS
      CCDS58657.1
      UniProtKB/Swiss-Prot
      Q03923
      Related
      ENSP00000300540.2, ENST00000300540.7
      Conserved Domains (3) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      pfam01352
      Location:443
      KRAB; KRAB box
      cl19880
      Location:5068
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    3. NM_001256173.2NP_001243102.1  zinc finger protein 85 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' coding region, uses a downstream start codon, and lacks an in-frame exon in the 3' coding region, compared to variant 3. The encoded isoform (d) is shorter at the N-terminus, compared to isoform c.
      Source sequence(s)
      AC008739, BC036394, BC047646, BP199573, DB119881
      UniProtKB/TrEMBL
      Q49A12
      Conserved Domains (3) summary
      COG5048
      Location:80487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:420440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:488512
      zf-H2C2_2; Zinc-finger double domain
    4. NM_003429.5NP_003420.2  zinc finger protein 85 isoform a

      See identical proteins and their annotated locations for NP_003420.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 3, resulting in an isoform (a) that is shorter than isoform c.
      Source sequence(s)
      AC008739, BC047646, BP199573, DB524732, U35376
      Consensus CDS
      CCDS32977.1
      UniProtKB/Swiss-Prot
      B9ZVP4, Q03923, Q6NVI0
      Related
      ENSP00000329793.7, ENST00000328178.13
      Conserved Domains (5) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:144558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:443
      KRAB; KRAB box
      pfam13465
      Location:552576
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_045830.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains alternate exon structure at its 5' and 3' regions, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most supported start codon, as used in variant 3, results in only a 10 aa ORF, and the transcript does not contain any other supported ORF that is likely to be translated.
      Source sequence(s)
      AC008739, BC008688, BC068066, BP199573
      Related
      ENST00000596476.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      20923251..20950697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439353.1XP_047295309.1  zinc finger protein 85 isoform X2

    2. XM_011528263.3XP_011526565.1  zinc finger protein 85 isoform X1

      See identical proteins and their annotated locations for XP_011526565.1

      Conserved Domains (5) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:189603
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:443
      KRAB; KRAB box
      pfam13465
      Location:597621
      zf-H2C2_2; Zinc-finger double domain
    3. XM_047439355.1XP_047295311.1  zinc finger protein 85 isoform X5

    4. XM_047439357.1XP_047295313.1  zinc finger protein 85 isoform X5

    5. XM_047439354.1XP_047295310.1  zinc finger protein 85 isoform X3

    6. XM_047439358.1XP_047295314.1  zinc finger protein 85 isoform X5

    7. XM_011528264.1XP_011526566.1  zinc finger protein 85 isoform X4

      See identical proteins and their annotated locations for XP_011526566.1

      UniProtKB/TrEMBL
      Q49A12
      Related
      ENST00000601023.2
      Conserved Domains (2) summary
      COG5048
      Location:169530
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:425445
      ZF_C2H2; C2H2 Zn finger [structural motif]
    8. XM_047439356.1XP_047295312.1  zinc finger protein 85 isoform X5

    9. XM_047439359.1XP_047295315.1  zinc finger protein 85 isoform X5

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315962.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      266527..293973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329586.1XP_054185561.1  zinc finger protein 85 isoform X2

    2. XM_054329585.1XP_054185560.1  zinc finger protein 85 isoform X1

    3. XM_054329589.1XP_054185564.1  zinc finger protein 85 isoform X5

    4. XM_054329591.1XP_054185566.1  zinc finger protein 85 isoform X5

    5. XM_054329587.1XP_054185562.1  zinc finger protein 85 isoform X3

    6. XM_054329592.1XP_054185567.1  zinc finger protein 85 isoform X5

    7. XM_054329588.1XP_054185563.1  zinc finger protein 85 isoform X4

      UniProtKB/TrEMBL
      Q49A12
    8. XM_054329590.1XP_054185565.1  zinc finger protein 85 isoform X5

    9. XM_054329593.1XP_054185568.1  zinc finger protein 85 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      21061743..21089195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321988.1XP_054177963.1  zinc finger protein 85 isoform X2

    2. XM_054321987.1XP_054177962.1  zinc finger protein 85 isoform X1

    3. XM_054321991.1XP_054177966.1  zinc finger protein 85 isoform X5

    4. XM_054321993.1XP_054177968.1  zinc finger protein 85 isoform X5

    5. XM_054321989.1XP_054177964.1  zinc finger protein 85 isoform X3

    6. XM_054321994.1XP_054177969.1  zinc finger protein 85 isoform X5

    7. XM_054321990.1XP_054177965.1  zinc finger protein 85 isoform X4

      UniProtKB/TrEMBL
      Q49A12
    8. XM_054321992.1XP_054177967.1  zinc finger protein 85 isoform X5

    9. XM_054321995.1XP_054177970.1  zinc finger protein 85 isoform X5