TAS2R31 taste 2 receptor member 31 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAS2R31provided by HGNC
Official Full Name: taste 2 receptor member 31provided by HGNC
Primary source: HGNC:HGNC:19113
See related: Ensembl:ENSG00000256436 MIM:612669; AllianceGenome:HGNC:19113
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T2R31; T2R44; T2R53; TAS2R44
Summary: TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]
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Genomic context

Location:: 12p13.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (11030387..11031407, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (10903718..10904738, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (11182986..11184006, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that NNS-sweetened products with acesulfame potassium (Ace-K) were consumed by 50% and 15% of mothers and children, respectively, with no association between intake and TAS2R31. The TAS2R31 WMVI haplotype was partly responsible for children's hedonic response to Ace-K, highlighting a potential role for inborn differences in vulnerability to overconsumption of Ace-K-containing products.
Title: Variation in the TAS2R31 bitter taste receptor gene relates to liking for the nonnutritive sweetener Acesulfame-K among children and adults.
Genotypes for the Val240Ile (rs10772423) SNP in TAS2R31 remains significant at a Bonferroni corrected alpha of 0.025.
Title: Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31.
Haplotype analyses revealed that most associations were spurious, arising from LD with variants in TAS2R31.
Title: Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners.
hT2R43 gene allele makes people more sensitive to the bitterness of an artificial sweetener, saccharin; in addition, a closely related gene's (hT2R44's) allele also makes people more sensitive to the bitterness of saccharin.
Title: Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.
hTAS2R43 and hTAS2R44 function as cognate bitter taste receptors and do not contribute to the sweet taste of saccharin and acesulfame K.
Title: Bitter taste receptors for saccharin and acesulfame K.
Activation by denatonium and 6-nitrosaccharin.
Title: Identification of ligands for two human bitter T2R receptors.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables bitter taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bitter taste receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: taste receptor type 2 member 31

Names: taste receptor type 2 member 44; taste receptor type 2 member 53; taste receptor, type 2, member 31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176885.2 → NP_795366.2 taste receptor type 2 member 31

See identical proteins and their annotated locations for NP_795366.2

Status: VALIDATED

Source sequence(s)

AC018630

Consensus CDS

CCDS53747.1

UniProtKB/Swiss-Prot

P59538, P59547, Q17R84, Q645X5

UniProtKB/TrEMBL

A0A0J9YWB3

Related

ENSP00000375093.2, ENST00000390675.2

Conserved Domains (1) summary

cd15027
Location:3 → 294

7tm_TAS2R43-like; mammalian taste receptor 2, subtype 43, and related proteins, member of the seven-transmembrane G protein-coupled receptor superfamily