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    KIAA1549L KIAA1549 like [ Homo sapiens (human) ]

    Gene ID: 25758, updated on 27-Nov-2024

    Summary

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    Official Symbol
    KIAA1549Lprovided by HGNC
    Official Full Name
    KIAA1549 likeprovided by HGNC
    Primary source
    HGNC:HGNC:24836
    See related
    Ensembl:ENSG00000110427 MIM:612297; AllianceGenome:HGNC:24836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G2; C11orf41; C11orf69
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 13.2) and skin (RPKM 0.8) See more
    Orthologs
    mouse all
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    Genomic context

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    See KIAA1549L in Genome Data Viewer
    Location:
    11p13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (33376108..33674102)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (33511580..33811113)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33397654..33695648)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4576 Neighboring gene ribosomal protein S24 pseudogene 15 Neighboring gene homeodomain interacting protein kinase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33666983-33667484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33667485-33667984 Neighboring gene uncharacterized LOC105376617 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:33676703-33677902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4582 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:33711673-33712872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4583 Neighboring gene chromosome 11 open reading frame 91 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33795080-33795580 Neighboring gene Sharpr-MPRA regulatory region 12829 Neighboring gene CD59 molecule (CD59 blood group) Neighboring gene F-box protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genetic Influences on Evening Preference Overlap with Those for Bipolar Disorder in a Sample of Mexican Americans and American Indians. Melroy-Greif WE, et al. Twin Res Hum Genet, 2017 Dec. PMID 29192581, Free PMC Article
    2. PAX5-KIAA1549L: a novel fusion gene in a case of pediatric B-cell precursor acute lymphoblastic leukemia. Anderl S, et al. Mol Cytogenet, 2015. PMID 26157485, Free PMC Article
    3. A genome-wide association study of attempted suicide. Willour VL, et al. Mol Psychiatry, 2012 Apr. PMID 21423239, Free PMC Article
    4. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article
    5. USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma. Saha G, et al. Oncogene, 2022 Nov. PMID 36243803

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of attempted suicide.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36988, MGC34830

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UPF0606 protein KIAA1549L
    Names
    UPF0606 protein C11orf41
    uncharacterized protein C11orf69

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410965.1 → NP_001397894.1  UPF0606 protein KIAA1549L isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL049575, AL049629, AL122015
      Consensus CDS
      CCDS91457.1
      UniProtKB/TrEMBL
      H0YDE5
      Related
      ENSP00000433481.3, ENST00000526400.7

    2. NM_012194.3 → NP_036326.3  UPF0606 protein KIAA1549L isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL049575, AL049629, AL122015, BC025668, DA034273, U10991
      Consensus CDS
      CCDS44565.3
      UniProtKB/Swiss-Prot
      B0QYU0, Q6ZVL6
      UniProtKB/TrEMBL
      A0A590UJI0
      Related
      ENSP00000499430.1, ENST00000658780.2
      Conserved Domains (2) summary
      PHA03247
      Location:6 → 418
      PHA03247; large tegument protein UL36; Provisional
      pfam12877
      Location:1228 → 1866
      DUF3827; Domain of unknown function (DUF3827)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      33376108..33674102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426719.1 → XP_047282675.1  UPF0606 protein KIAA1549L isoform X1

    2. XM_005252848.4 → XP_005252905.2  UPF0606 protein KIAA1549L isoform X2

    3. XM_047426720.1 → XP_047282676.1  UPF0606 protein KIAA1549L isoform X3

    4. XM_005252847.4 → XP_005252904.2  UPF0606 protein KIAA1549L isoform X5

      UniProtKB/TrEMBL
      Q12914
      Conserved Domains (2) summary
      PHA03255
      Location:607 → 741
      PHA03255; BDLF3; Provisional
      pfam12877
      Location:976 → 1614
      DUF3827; Domain of unknown function (DUF3827)

    5. XM_017017486.2 → XP_016872975.1  UPF0606 protein KIAA1549L isoform X7

    6. XM_047426721.1 → XP_047282677.1  UPF0606 protein KIAA1549L isoform X4

    7. XM_047426722.1 → XP_047282678.1  UPF0606 protein KIAA1549L isoform X6

      Related
      ENSP00000265654.6, ENST00000265654.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      33511580..33811113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368332.1 → XP_054224307.1  UPF0606 protein KIAA1549L isoform X1

    2. XM_054368333.1 → XP_054224308.1  UPF0606 protein KIAA1549L isoform X2

    3. XM_054368334.1 → XP_054224309.1  UPF0606 protein KIAA1549L isoform X3

    4. XM_054368336.1 → XP_054224311.1  UPF0606 protein KIAA1549L isoform X5

    5. XM_054368338.1 → XP_054224313.1  UPF0606 protein KIAA1549L isoform X7

    6. XM_054368335.1 → XP_054224310.1  UPF0606 protein KIAA1549L isoform X4

    7. XM_054368337.1 → XP_054224312.1  UPF0606 protein KIAA1549L isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZVL6.2 GenPept UniProtKB/Swiss-Prot:Q6ZVL6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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