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    GOLPH3L golgi phosphoprotein 3 like [ Homo sapiens (human) ]

    Gene ID: 55204, updated on 10-Dec-2024

    Summary

    Official Symbol
    GOLPH3Lprovided by HGNC
    Official Full Name
    golgi phosphoprotein 3 likeprovided by HGNC
    Primary source
    HGNC:HGNC:24882
    See related
    Ensembl:ENSG00000143457 MIM:612208; AllianceGenome:HGNC:24882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPP34R
    Summary
    The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in colon (RPKM 16.0), thyroid (RPKM 15.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GOLPH3L in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150646230..150697154, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149770312..149822032, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150618706..150669630, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150598651-150599182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150601815-150602782 Neighboring gene uncharacterized LOC112268239 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150602783-150603752 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:150606865-150607490 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150607491-150608116 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150608117-150608742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150608743-150609367 Neighboring gene endosulfine alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150610512-150611128 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150613593-150614208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150619341-150619842 Neighboring gene RNA, U6 small nuclear 1042, pseudogene Neighboring gene HORMA domain containing 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150700761-150701526 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150703034 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150703366 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150707596 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150709723 Neighboring gene cathepsin S Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150721175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150721583-150722232 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150727539 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150728676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1699 Neighboring gene melanoma risk locus-associated MPRA allelic enhancers 1:150738197 and 1:150738200

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
    EBI GWAS Catalog
    Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10687

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cargo adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi vesicle budding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane IC
    Inferred by Curator
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network membrane IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    Golgi phosphoprotein 3-like
    Names
    GPP34-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018178.6NP_060648.2  Golgi phosphoprotein 3-like

      See identical proteins and their annotated locations for NP_060648.2

      Status: REVIEWED

      Source sequence(s)
      AL356292, AL356356
      Consensus CDS
      CCDS966.1
      UniProtKB/Swiss-Prot
      B1AN09, B7Z6N3, Q9H4A5, Q9NVK0
      UniProtKB/TrEMBL
      Q5T5I6
      Related
      ENSP00000271732.3, ENST00000271732.8
      Conserved Domains (1) summary
      pfam05719
      Location:48268
      GPP34; Golgi phosphoprotein 3 (GPP34)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      150646230..150697154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424285.1XP_047280241.1  Golgi phosphoprotein 3-like isoform X2

    2. XM_006711428.3XP_006711491.1  Golgi phosphoprotein 3-like isoform X1

      UniProtKB/TrEMBL
      Q5T5I6
      Conserved Domains (1) summary
      pfam05719
      Location:62273
      GPP34; Golgi phosphoprotein 3 (GPP34)
    3. XM_047424286.1XP_047280242.1  Golgi phosphoprotein 3-like isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      149770312..149822032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337417.1XP_054193392.1  Golgi phosphoprotein 3-like isoform X2

    2. XM_054337416.1XP_054193391.1  Golgi phosphoprotein 3-like isoform X1

      UniProtKB/TrEMBL
      Q5T5I6
    3. XM_054337418.1XP_054193393.1  Golgi phosphoprotein 3-like isoform X3