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    GLIPR1L2 GLIPR1 like 2 [ Homo sapiens (human) ]

    Gene ID: 144321, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GLIPR1L2provided by HGNC
    Official Full Name
    GLIPR1 like 2provided by HGNC
    Primary source
    HGNC:HGNC:28592
    See related
    Ensembl:ENSG00000180481 MIM:610394; AllianceGenome:HGNC:28592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the cysteine-rich secretory protein, antigen 5, and pathogenesis-related 1 superfamily. Members of this family have roles in a variety of processes, including cancer and immune defense. This gene is located in a cluster with two related genes on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in testis (RPKM 10.0), ovary (RPKM 1.3) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GLIPR1L2 in Genome Data Viewer
    Location:
    12q21.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (75391089..75432688)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (75365673..75407236)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75784869..75826468)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcyphosine 2 Neighboring gene necdin, MAGE family member pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4661 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75734995-75735496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75735497-75735996 Neighboring gene GLIPR1 like 1 Neighboring gene uncharacterized LOC124902968 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:75770264-75770835 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:75784671-75784843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75880921-75881422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75881423-75881922 Neighboring gene GLIPR1 antisense RNA 1 Neighboring gene GLI pathogenesis related 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75904602-75905146 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75905147-75905690 Neighboring gene KRR1 small subunit processome component homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Examining Hedgehog pathway genes GLI3, SHH, and PTCH1 and the p53 target GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster using fluorescence in situ hybridization uncovers GLIPR1/GLIPR1L1/GLIPR1L2 deletion in 9% of patients with multiple myeloma. Tam M, et al. J Assoc Genet Technol, 2010. PMID 20978342
    2. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Ren C, et al. Genomics, 2006 Aug. PMID 16714093
    3. Protein phosphatase 1α interacting proteins in the human brain. Esteves SL, et al. OMICS, 2012 Jan-Feb. PMID 22321011, Free PMC Article
    4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
    5. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. Moutaoufik MT, et al. iScience, 2019 Sep 27. PMID 31536960, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC39497

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GLIPR1-like protein 2
    Names
    GLI pathogenesis related 1 like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270396.2 → NP_001257325.1  GLIPR1-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001257325.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AA649108, AC121761, BC016749, BX640916
      Consensus CDS
      CCDS58258.1
      UniProtKB/Swiss-Prot
      Q4G1C9, Q6MZS1, Q8N6N0, Q8NA43
      Related
      ENSP00000448248.1, ENST00000550916.6
      Conserved Domains (1) summary
      cd05385
      Location:52 → 195
      SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

    2. NM_152436.3 → NP_689649.1  GLIPR1-like protein 2 isoform 2

      See identical proteins and their annotated locations for NP_689649.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate exon structure in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC121761, BC016749, BC029557
      Consensus CDS
      CCDS9010.1
      UniProtKB/Swiss-Prot
      Q4G1C9
      Related
      ENSP00000317385.4, ENST00000320460.8
      Conserved Domains (1) summary
      cd05385
      Location:52 → 195
      SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

    RNA

    1. NR_072995.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA649108, AC121761, BC016749, BX640916

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      75391089..75432688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537949.2 → XP_011536251.1  GLIPR1-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011536251.1

      UniProtKB/Swiss-Prot
      Q4G1C9
      Related
      ENSP00000367963.3, ENST00000378692.7
      Conserved Domains (1) summary
      cl00133
      Location:1 → 88
      SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...

    2. XM_047428339.1 → XP_047284295.1  GLIPR1-like protein 2 isoform X1

    3. XM_047428338.1 → XP_047284294.1  GLIPR1-like protein 2 isoform X1

    4. XM_024448850.2 → XP_024304618.1  GLIPR1-like protein 2 isoform X2

      Conserved Domains (1) summary
      cl00133
      Location:1 → 118
      SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...

    5. XM_047428342.1 → XP_047284298.1  GLIPR1-like protein 2 isoform X1

    6. XM_047428341.1 → XP_047284297.1  GLIPR1-like protein 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      75365673..75407236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371163.1 → XP_054227138.1  GLIPR1-like protein 2 isoform X1

    2. XM_054371168.1 → XP_054227143.1  GLIPR1-like protein 2 isoform X3

    3. XM_054371164.1 → XP_054227139.1  GLIPR1-like protein 2 isoform X1

    4. XM_054371167.1 → XP_054227142.1  GLIPR1-like protein 2 isoform X2

    5. XM_054371166.1 → XP_054227141.1  GLIPR1-like protein 2 isoform X1

    6. XM_054371165.1 → XP_054227140.1  GLIPR1-like protein 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G1C9.2 GenPept UniProtKB/Swiss-Prot:Q4G1C9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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