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    Pold3 DNA polymerase delta 3, accessory subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pold3provided by RGD
    Official Full Name
    DNA polymerase delta 3, accessory subunitprovided by RGD
    Primary source
    RGD:1312027
    See related
    EnsemblRapid:ENSRNOG00000018411 AllianceGenome:RGD:1312027
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to DNA-directed DNA polymerase activity. Involved in DNA-templated DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of delta DNA polymerase complex and zeta DNA polymerase complex. Orthologous to human POLD3 (DNA polymerase delta 3, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 127.6), Thymus (RPKM 111.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pold3 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (163830217..163870015, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154417893..154456687, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165085142..165122385, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene chordin-like 2 Neighboring gene ribosomal protein L23,pseudogene 3 Neighboring gene uncharacterized LOC100912071 Neighboring gene lipoyl(octanoyl) transferase 2 Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DNA polymerases and repair synthesis in NER in human cells. Lehmann AR. DNA Repair (Amst), 2011 Jul 15. PMID 21601536
    2. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. López-Girona A, et al. Biochem Biophys Res Commun, 1995 Dec 14. PMID 7503737
    3. Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. Ducoux M, et al. J Biol Chem, 2001 Dec 28. PMID 11595739
    4. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Ogi T, et al. Mol Cell, 2010 Mar 12. PMID 20227374
    5. DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ. Baranovskiy AG, et al. J Biol Chem, 2012 May 18. PMID 22465957, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA strand elongation involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA synthesis involved in UV-damage excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in error-prone translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair, DNA gap filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair, DNA gap filling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of delta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of delta DNA polymerase complex IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of delta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of zeta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase delta subunit 3
    Names
    DNA-directed DNA polymerase delta 3
    polymerase (DNA) delta 3, accessory subunit
    polymerase (DNA-directed), delta 3, accessory subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024750.1 → NP_001019921.1  DNA polymerase delta subunit 3

      See identical proteins and their annotated locations for NP_001019921.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098010
      UniProtKB/TrEMBL
      A6I6L5, F6T1W7, Q4V7D0
      Related
      ENSRNOP00000079366.2, ENSRNOT00000095168.2
      Conserved Domains (1) summary
      pfam09507
      Location:19 → 462
      CDC27; DNA polymerase subunit Cdc27

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      163830217..163870015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106084.2 → XP_038962012.2  DNA polymerase delta subunit 3 isoform X1

      UniProtKB/TrEMBL
      A6I6L5

    2. XM_063285127.1 → XP_063141197.1  DNA polymerase delta subunit 3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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