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    C4orf33 chromosome 4 open reading frame 33 [ Homo sapiens (human) ]

    Gene ID: 132321, updated on 27-Nov-2024

    Summary

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    Official Symbol
    C4orf33provided by HGNC
    Official Full Name
    chromosome 4 open reading frame 33provided by HGNC
    Primary source
    HGNC:HGNC:27025
    See related
    Ensembl:ENSG00000151470 AllianceGenome:HGNC:27025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in colon (RPKM 3.9), duodenum (RPKM 3.8) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
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    Genomic context

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    See C4orf33 in Genome Data Viewer
    Location:
    4q28.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (129093712..129116637)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (132397882..132420798)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (130014867..130037792)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr4:129697052-129697573 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129723780-129724699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129734111-129734692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:129734693-129735274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21898 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:129752609-129753288 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:129753289-129753968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129756920-129757462 Neighboring gene jade family PHD finger 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21899 Neighboring gene sodium channel and clathrin linker 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21902 Neighboring gene CDRT15 pseudogene 11 Neighboring gene zinc finger SWIM-type containing 5 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Tsuritani K, et al. Genome Res, 2007 Jul. PMID 17567985, Free PMC Article
    2. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Hou P, et al. Cancer Res, 2017 Aug 15. PMID 28625976, Free PMC Article
    3. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
    4. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
    5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of chromosome 4 open reading frame 33 (C4orf33) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33703

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UPF0462 protein C4orf33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099783.2 → NP_001093253.1  UPF0462 protein C4orf33

      See identical proteins and their annotated locations for NP_001093253.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC093826, BC032582, BE566349, BQ549846, BU783470, CN483524
      Consensus CDS
      CCDS3741.1
      UniProtKB/Swiss-Prot
      D3DNY2, Q6PJF3, Q8N1A6, Q8NBC5
      UniProtKB/TrEMBL
      D6RIT3
      Related
      ENSP00000401090.1, ENST00000425929.6
      Conserved Domains (1) summary
      cl14783
      Location:42 → 171
      DOMON_like; Domon-like ligand-binding domains

    2. NM_173487.3 → NP_775758.2  UPF0462 protein C4orf33

      See identical proteins and their annotated locations for NP_775758.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC093826, BC032582, BP871612, BQ549846, BU783470
      Consensus CDS
      CCDS3741.1
      UniProtKB/Swiss-Prot
      D3DNY2, Q6PJF3, Q8N1A6, Q8NBC5
      UniProtKB/TrEMBL
      D6RIT3
      Related
      ENSP00000281146.4, ENST00000281146.9
      Conserved Domains (1) summary
      cl14783
      Location:42 → 171
      DOMON_like; Domon-like ligand-binding domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      129093712..129116637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007724.2 → XP_016863213.1  UPF0462 protein C4orf33 isoform X1

      UniProtKB/TrEMBL
      D6RIT3
      Related
      ENSP00000427406.1, ENST00000502887.5
      Conserved Domains (1) summary
      cl14783
      Location:42 → 94
      DOMON_like; Domon-like ligand-binding domains

    2. XM_047449598.1 → XP_047305554.1  UPF0462 protein C4orf33 isoform X1

    3. XM_047449599.1 → XP_047305555.1  UPF0462 protein C4orf33 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      132397882..132420798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348895.1 → XP_054204870.1  UPF0462 protein C4orf33 isoform X1

    2. XM_054348893.1 → XP_054204868.1  UPF0462 protein C4orf33 isoform X1

    3. XM_054348894.1 → XP_054204869.1  UPF0462 protein C4orf33 isoform X2

    4. XM_054348896.1 → XP_054204871.1  UPF0462 protein C4orf33 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N1A6.2 GenPept UniProtKB/Swiss-Prot:Q8N1A6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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