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    IGFL3 IGF like family member 3 [ Homo sapiens (human) ]

    Gene ID: 388555, updated on 27-Nov-2024

    Summary

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    Official Symbol
    IGFL3provided by HGNC
    Official Full Name
    IGF like family member 3provided by HGNC
    Primary source
    HGNC:HGNC:32930
    See related
    Ensembl:ENSG00000188624 MIM:610546; AllianceGenome:HGNC:32930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNQ483
    Summary
    IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See IGFL3 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46120067..46124688, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48947474..48952095, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46623324..46627945, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene IGF like family member 4 Neighboring gene IGF like family member 2 Neighboring gene solute carrier family 30 member 5 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46636065-46636896 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:46636897-46637728 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46637729-46638559 Neighboring gene TGFB induced factor homeobox 1 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:46662347-46663546 Neighboring gene uncharacterized LOC105372424 Neighboring gene NANOG hESC enhancer GRCh37_chr19:46673889-46674439

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. Emtage P, et al. Genomics, 2006 Oct. PMID 16890402
    2. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. Lobito AA, et al. J Biol Chem, 2011 May 27. PMID 21454693, Free PMC Article
    3. Human gingiva transcriptome during wound healing. Wang Y, et al. J Clin Periodontol, 2017 Apr. PMID 28005267
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin growth factor-like family member 3
    Names
    RPRC483

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207393.2 → NP_997276.1  insulin growth factor-like family member 3 precursor

      See identical proteins and their annotated locations for NP_997276.1

      Status: VALIDATED

      Source sequence(s)
      AC007785, AY358434
      Consensus CDS
      CCDS33058.1
      UniProtKB/Swiss-Prot
      Q6UXB1
      Related
      ENSP00000344860.2, ENST00000341415.3
      Conserved Domains (1) summary
      pfam14653
      Location:33 → 115
      IGFL; Insulin growth factor-like family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      46120067..46124688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526953.3 → XP_011525255.1  insulin growth factor-like family member 3 isoform X1

      Conserved Domains (1) summary
      pfam14653
      Location:27 → 115
      IGFL; Insulin growth factor-like family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      48947474..48952095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320963.1 → XP_054176938.1  insulin growth factor-like family member 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UXB1.1 GenPept UniProtKB/Swiss-Prot:Q6UXB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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