MIR195 microRNA 195 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR195provided by HGNC
Official Full Name: microRNA 195provided by HGNC
Primary source: HGNC:HGNC:31566
See related: Ensembl:ENSG00000284112 MIM:610718; miRBase:MI0000489; AllianceGenome:HGNC:31566
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN195; mir-195; miRNA195
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 17p13.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (7017615..7017701, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (6918215..6918301, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (6920934..6921020, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsa-miR-15b-5p/miR-195-5p Controls Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells Through Regulating Indian Hedgehog Expression.
Title: Hsa-miR-15b-5p/miR-195-5p Controls Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells Through Regulating Indian Hedgehog Expression.
LINC00520 promotes colorectal cancer progression through miRNA-195-3p / NAT2 axis.
Title: LINC00520 promotes colorectal cancer progression through miRNA-195-3p / NAT2 axis.
Analysis of miR-497/195 cluster identifies new therapeutic targets in cervical cancer.
Title: Analysis of miR-497/195 cluster identifies new therapeutic targets in cervical cancer.
Identification of a Novel miR-195-5p/PNN Axis in Colorectal Cancer.
Title: Identification of a Novel miR-195-5p/PNN Axis in Colorectal Cancer.
miR-497/195 Cluster Affects the Development of Colorectal Cancer by Targeting FRA1.
Title: miR-497/195 Cluster Affects the Development of Colorectal Cancer by Targeting FRA1.
Exosome-transported of circ_0081069 induces SPIN1 production by binding to miR-195-5p to inhibit radiosensitivity in esophageal squamous cell carcinoma.
Title: Exosome-transported of circ_0081069 induces SPIN1 production by binding to miR-195-5p to inhibit radiosensitivity in esophageal squamous cell carcinoma.
Dampening HOTAIR sensitizes the gastric cancer cells to oxaliplatin through miR-195-5p and ABCG2 pathway.
Title: Dampening HOTAIR sensitizes the gastric cancer cells to oxaliplatin through miR-195-5p and ABCG2 pathway.
ATG9A modulated by miR-195-5p can boost the malignant progression of cervical cancer cells.
Title: ATG9A modulated by miR-195-5p can boost the malignant progression of cervical cancer cells.
MicroRNA and gynecological cancers: Focus on miR-195.
Title: MicroRNA and gynecological cancers: Focus on miR-195.
Inhibiting miR-195-5p Induces Proliferation of Human Corneal Endothelial Cells.
Title: Inhibiting miR-195-5p Induces Proliferation of Human Corneal Endothelial Cells.

Submit: New GeneRIF Correction See all GeneRIFs (280)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA base-pairing translational repressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac muscle hypertrophy	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle tissue growth involved in heart morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell growth involved in cardiac muscle cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in miRNA-mediated gene silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	HDA more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuroinflammatory response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of vascular endothelial growth factor production	HMP more info	PubMed
involved_in negative regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cardiac muscle cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of connective tissue replacement	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of extracellular matrix disassembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within regulation of glucosylceramide catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to ischemia	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.