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    METTL9 methyltransferase 9, His-X-His N1(pi)-histidine [ Homo sapiens (human) ]

    Gene ID: 51108, updated on 27-Dec-2024

    Summary

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    Official Symbol
    METTL9provided by HGNC
    Official Full Name
    methyltransferase 9, His-X-His N1(pi)-histidineprovided by HGNC
    Primary source
    HGNC:HGNC:24586
    See related
    Ensembl:ENSG00000197006 MIM:609388; AllianceGenome:HGNC:24586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DREV; PAP1; DREV1; CGI-81; hMETTL9
    Summary
    Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to be involved in methylation. Is active in endoplasmic reticulum and mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 38.8), adrenal (RPKM 37.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See METTL9 in Genome Data Viewer
    Location:
    16p12.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (21597208..21657471)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (22559463..22619737, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21608529..21668792)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:21529065-21529231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21531393-21532126 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21532127-21532859 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21532860-21533594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21535062-21535794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21536490-21537300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21537301-21538111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21538112-21538922 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43111 Neighboring gene solute carrier family 7 member 5 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21549325-21549826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21549827-21550326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21552333-21553071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10557 Neighboring gene carbonic anhydrase 5A pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21561118-21561618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21562361-21562862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21565604-21566414 Neighboring gene uncharacterized LOC101927814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7257 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:21611613-21612177 Neighboring gene uncharacterized LOC124903663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10558 Neighboring gene RNA, U6 small nuclear 1005, pseudogene Neighboring gene RNA, U6 small nuclear 196, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10559 Neighboring gene immunoglobulin superfamily member 6 Neighboring gene otoancorin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10560 Neighboring gene uncharacterized LOC105371126 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:21801669-21802169

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular basis for METTL9-mediated N1-histidine methylation. Wang X, et al. Cell Discov, 2023 Apr 4. PMID 37015930, Free PMC Article
    2. Molecular basis for protein histidine N1-specific methylation of the "His-x-His" motifs by METTL9. Zhao W, et al. Cell Insight, 2023 Jun. PMID 37398635, Free PMC Article
    3. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth. Lv M, et al. Protein Cell, 2021 Dec. PMID 34218407, Free PMC Article
    4. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Davydova E, et al. Nat Commun, 2021 Feb 9. PMID 33563959, Free PMC Article
    5. Effects of exogenous p53 transfection on the gene expression in the human brain glioma cell line U251. Shu KX, et al. Colloids Surf B Biointerfaces, 2006 Feb 1. PMID 16413759

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6.
      Title: METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6.
    2. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth.
      Title: METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth.
    3. siRNA screening identifies METTL9 as a histidine Npi-methyltransferase that targets the proinflammatory protein S100A9.
      Title: siRNA screening identifies METTL9 as a histidine Nπ-methyltransferase that targets the proinflammatory protein S100A9.
    4. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
      Title: The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    6. cloned the PAP1 gene, a p53 activated protein, from a U251-pTet-p53 cell line which carried a wild-type p53 transgene.
      Title: Characterization of the human PAP1 gene and its homologue possible involvement in mouse embryonic development.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21912

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-L-histidine N-pros-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein-L-histidine N-pros-methyltransferase
    Names
    CTB-31N19.3
    DORA reverse strand protein 1
    methyltransferase 9, His-X-His N1-histidine
    methyltransferase like 9
    methyltransferase-like protein 9
    p53 activated protein 1
    NP_001070648.1
    NP_001275588.1
    NP_001275589.1
    NP_057109.3
    XP_054188124.1
    XP_054236409.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077180.3 → NP_001070648.1  protein-L-histidine N-pros-methyltransferase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001070648.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AJ278578, BC000195
      Consensus CDS
      CCDS45440.1
      UniProtKB/TrEMBL
      B2R7Q6
      Related
      ENSP00000379335.4, ENST00000396014.8
      Conserved Domains (1) summary
      pfam05219
      Location:56 → 316
      DREV; DREV methyltransferase

    2. NM_001288659.2 → NP_001275588.1  protein-L-histidine N-pros-methyltransferase isoform 3

      See identical proteins and their annotated locations for NP_001275588.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC005632, BC000195, BG183771
      UniProtKB/TrEMBL
      Q8TD49
      Related
      ENSP00000454733.1, ENST00000567404.5
      Conserved Domains (1) summary
      pfam05219
      Location:16 → 277
      DREV; DREV methyltransferase

    3. NM_001288660.2 → NP_001275589.1  protein-L-histidine N-pros-methyltransferase isoform 4

      See identical proteins and their annotated locations for NP_001275589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate in-frame splice site in the 3' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC005632, AJ278578, BC000195, BG183771
      UniProtKB/TrEMBL
      Q8TD49
      Conserved Domains (1) summary
      pfam05219
      Location:16 → 276
      DREV; DREV methyltransferase

    4. NM_016025.5 → NP_057109.3  protein-L-histidine N-pros-methyltransferase isoform 1 precursor

      See identical proteins and their annotated locations for NP_057109.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC000195, CF146931
      Consensus CDS
      CCDS10598.2
      UniProtKB/Swiss-Prot
      Q8NBT8, Q9BWJ7, Q9H1A2, Q9H1A3, Q9Y390
      UniProtKB/TrEMBL
      B2R7Q6
      Related
      ENSP00000350874.3, ENST00000358154.8
      Conserved Domains (1) summary
      pfam05219
      Location:56 → 317
      DREV; DREV methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      21597208..21657471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_017852933.1 Reference GRCh38.p14 PATCHES

      Range
      1447357..1507609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332149.1 → XP_054188124.1  protein-L-histidine N-pros-methyltransferase isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      22559463..22619737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380434.1 → XP_054236409.1  protein-L-histidine N-pros-methyltransferase isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H1A3.1 GenPept UniProtKB/Swiss-Prot:Q9H1A3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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