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    Zar1l zygote arrest 1-like [ Mus musculus (house mouse) ]

    Gene ID: 545824, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zar1lprovided by MGI
    Official Full Name
    zygote arrest 1-likeprovided by MGI
    Primary source
    MGI:MGI:3690051
    See related
    Ensembl:ENSMUSG00000056586 AllianceGenome:MGI:3690051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XM_359419
    Summary
    Enables mRNA 3'-UTR binding activity. Involved in negative regulation of translation and oocyte maturation. Located in cytoplasm. Is active in intracellular membraneless organelle. Orthologous to human ZAR1L (zygote arrest 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 1.8), cortex adult (RPKM 0.4) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Zar1l in Genome Data Viewer
    Location:
    5 G3; 5 89.51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (150430520..150441659, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (150507055..150518194, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene FRY microtubule binding protein Neighboring gene predicted gene, 57745 Neighboring gene STARR-seq mESC enhancer starr_14955 Neighboring gene predicted gene 5 Neighboring gene breast cancer 2, early onset Neighboring gene predicted gene, 25284 Neighboring gene predicted gene, 23641

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice. Pham AH, et al. Cells, 2024 May 8. PMID 38786026, Free PMC Article
    2. Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest. Hu J, et al. Dev Dyn, 2010 Feb. PMID 20014101
    3. ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation. Rong Y, et al. Nucleic Acids Res, 2019 Dec 2. PMID 31598710, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A previously unrecognized role of ZAR1/2 in regulating the maternal transcriptome and translational activation in maturing oocytes.
      Title: ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.
    2. ZAR1L and ZAR1 may comprise a novel family of processing-body/chromatoid-body components that potentially function as RNA regulators in early embryos.
      Title: Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oocyte maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membraneless organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein ZAR1-like
    Names
    ZAR1-like protein
    zygote arrest protein 1-like
    zygote arrest protein 2
    zygotic arrest 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159693.2 → NP_001153165.1  protein ZAR1-like

      See identical proteins and their annotated locations for NP_001153165.1

      Status: VALIDATED

      Source sequence(s)
      CO801197, FJ858201
      Consensus CDS
      CCDS51709.1
      UniProtKB/Swiss-Prot
      C3VD30
      Related
      ENSMUSP00000114116.2, ENSMUST00000118769.2
      Conserved Domains (1) summary
      pfam13695
      Location:196 → 280
      zf-3CxxC; Zinc-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      150430520..150441659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165315.1 → XP_036021208.1  protein ZAR1-like isoform X2

      Conserved Domains (1) summary
      pfam13695
      Location:233 → 315
      zf-3CxxC; Zinc-binding domain

    2. XM_011241026.2 → XP_011239328.1  protein ZAR1-like isoform X4

      Conserved Domains (1) summary
      pfam13695
      Location:197 → 234
      zf-3CxxC; Zinc-binding domain

    3. XM_036165314.1 → XP_036021207.1  protein ZAR1-like isoform X1

      Conserved Domains (1) summary
      pfam13695
      Location:233 → 283
      zf-3CxxC; Zinc-binding domain

    4. XM_036165317.1 → XP_036021210.1  protein ZAR1-like isoform X3

      Conserved Domains (1) summary
      pfam13695
      Location:233 → 283
      zf-3CxxC; Zinc-binding domain

    5. XM_036165316.1 → XP_036021209.1  protein ZAR1-like isoform X3

      Conserved Domains (1) summary
      pfam13695
      Location:233 → 283
      zf-3CxxC; Zinc-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C3VD30.1 GenPept UniProtKB/Swiss-Prot:C3VD30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials