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    H2AC7 H2A clustered histone 7 [ Homo sapiens (human) ]

    Gene ID: 3013, updated on 27-Nov-2024

    Summary

    Official Symbol
    H2AC7provided by HGNC
    Official Full Name
    H2A clustered histone 7provided by HGNC
    Primary source
    HGNC:HGNC:4729
    See related
    Ensembl:ENSG00000196866 MIM:602792; AllianceGenome:HGNC:4729
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H2A.3; H2A/g; H2AFG; HIST1H2AD
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
    Orthologs
    NEW
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    Genomic context

    See H2AC7 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26198784..26199293, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26067250..26067759, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26199012..26199521, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24199 Neighboring gene H4 clustered histone 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26196641-26197242 Neighboring gene H1.12 linker histone, cluster member, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26197243-26197843 Neighboring gene H3 clustered histone 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24203 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:26199013-26200212 Neighboring gene H2B clustered histone 7 Neighboring gene ribosomal protein S10 pseudogene 1

    Genomic regions, transcripts, and products

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: H3C4

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H2A type 1-D
    Names
    H2A histone family, member G
    histone 1, H2ad
    histone H2A.3
    histone H2A/g
    histone H2AD
    histone cluster 1 H2A family member d
    histone cluster 1, H2ad

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021065.3NP_066409.1  histone H2A type 1-D

      See identical proteins and their annotated locations for NP_066409.1

      Status: REVIEWED

      Source sequence(s)
      AL031777
      Consensus CDS
      CCDS4591.1
      UniProtKB/Swiss-Prot
      A0PK91, P20671, P57754, Q6FGY6
      UniProtKB/TrEMBL
      B2R5B6
      Related
      ENSP00000341094.2, ENST00000341023.2
      Conserved Domains (1) summary
      PTZ00017
      Location:1130
      PTZ00017; histone H2A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26198784..26199293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      26067250..26067759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)