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    MEG8 maternally expressed 8, small nucleolar RNA host gene [ Homo sapiens (human) ]

    Gene ID: 79104, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MEG8provided by HGNC
    Official Full Name
    maternally expressed 8, small nucleolar RNA host geneprovided by HGNC
    Primary source
    HGNC:HGNC:14574
    See related
    MIM:613648; AllianceGenome:HGNC:14574
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Bsr; Irm; Rian; SNHG23; SNHG24; lnc-MGC; LINC00024; NCRNA00024
    Summary
    This gene is located in a cluster of imprinted genes on chromosome 14q32.3. It encodes a a non-protein coding transcript that is preferentially expressed from the maternal allele in skeletal muscle, and appears to be coordinately regulated with other imprinted genes in this region. [provided by RefSeq, Oct 2010]
    Expression
    Biased expression in adrenal (RPKM 3.1), placenta (RPKM 2.2) and 6 other tissues See more
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    Genomic context

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    See MEG8 in Genome Data Viewer
    Location:
    14q32.2-q32.31
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (100889649..100999113)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (95125076..95234524)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (101355986..101465450)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13483 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_33596 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_33604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101357417-101357918 Neighboring gene retrotransposon Gag like 1 Neighboring gene microRNA 432 Neighboring gene microRNA 136 Neighboring gene small nucleolar RNA, C/D box 112 Neighboring gene microRNA 370 Neighboring gene small nucleolar RNA, C/D box 113-1 Neighboring gene small nucleolar RNA, C/D box 113-2 Neighboring gene small nucleolar RNA, C/D box 113-3 Neighboring gene small nucleolar RNA, C/D box 113-4 Neighboring gene small nucleolar RNA, C/D box 113-5 Neighboring gene small nucleolar RNA, C/D box 113-6 Neighboring gene small nucleolar RNA, C/D box 113-7 Neighboring gene small nucleolar RNA, C/D box 113-8 Neighboring gene small nucleolar RNA, C/D box 113-9 Neighboring gene small nucleolar RNA, C/D box 114-1 Neighboring gene small nucleolar RNA, C/D box 114-2 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene small nucleolar RNA, C/D box 114-3 Neighboring gene small nucleolar RNA, C/D box 114-4 Neighboring gene small nucleolar RNA, C/D box 114-5 Neighboring gene small nucleolar RNA, C/D box 114-6 Neighboring gene small nucleolar RNA, C/D box 114-7 Neighboring gene small nucleolar RNA, C/D box 114-8 Neighboring gene small nucleolar RNA, C/D box 114-10 Neighboring gene small nucleolar RNA, C/D box 114-9 Neighboring gene small nucleolar RNA, C/D box 114-11 Neighboring gene small nucleolar RNA, C/D box 114-12 Neighboring gene small nucleolar RNA, C/D box 114-13 Neighboring gene small nucleolar RNA, C/D box 114-14 Neighboring gene small nucleolar RNA, C/D box 114-15 Neighboring gene small nucleolar RNA, C/D box 114-16 Neighboring gene small nucleolar RNA, C/D box 114-17 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene small nucleolar RNA, C/D box 114-18 Neighboring gene small nucleolar RNA, C/D box 114-19 Neighboring gene uncharacterized LOC124903417 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene small nucleolar RNA, C/D box 114-20 Neighboring gene small nucleolar RNA, C/D box 114-21 Neighboring gene small nucleolar RNA, C/D box 114-22 Neighboring gene small nucleolar RNA, C/D box 114-23 Neighboring gene small nucleolar RNA, C/D box 114-24 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:101454444-101455643 Neighboring gene small nucleolar RNA, C/D box 114-25 Neighboring gene small nucleolar RNA, C/D box 114-26 Neighboring gene small nucleolar RNA, C/D box 114-27 Neighboring gene small nucleolar RNA, C/D box 114-28 Neighboring gene small nucleolar RNA, C/D box 114-29 Neighboring gene small nucleolar RNA, C/D box 114-30 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene small nucleolar RNA, C/D box 114-31 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:101467025-101468224 Neighboring gene mucin-2-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101474981-101475704 Neighboring gene microRNA 379 Neighboring gene microRNA 411

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers. Du Z, et al. Curr Pharm Des, 2022. PMID 35578848
    2. New insights into the imprinted MEG8-DMR in 14q32 and clinical and molecular description of novel patients with Temple syndrome. Beygo J, et al. Eur J Hum Genet, 2017 Aug. PMID 28635951, Free PMC Article
    3. Silencing of lncRNA MEG8 Represses the Viability, Migration, and Invasion of Wilms' Tumor Cells through Mediating miR-23a-3p/CRK Axis. Shen J, et al. Urol Int, 2022. PMID 34518485
    4. MEG8 long noncoding RNA contributes to epigenetic progression of the epithelial-mesenchymal transition of lung and pancreatic cancer cells. Terashima M, et al. J Biol Chem, 2018 Nov 23. PMID 30262664, Free PMC Article
    5. LncRNA MEG8 promotes tumor progression of non-small cell lung cancer via regulating miR-107/CDK6 axis. Liu Y, et al. Anticancer Drugs, 2020 Nov. PMID 32649368

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA MEG8 ameliorates Parkinson's disease neuro-inflammation through miR-485-3p/FBXO45 axis.
      Title: LncRNA MEG8 ameliorates Parkinson's disease neuro-inflammation through miR-485-3p/FBXO45 axis.
    2. Silencing of lncRNA MEG8 Represses the Viability, Migration, and Invasion of Wilms' Tumor Cells through Mediating miR-23a-3p/CRK Axis.
      Title: Silencing of lncRNA MEG8 Represses the Viability, Migration, and Invasion of Wilms' Tumor Cells through Mediating miR-23a-3p/CRK Axis.
    3. MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers.
      Title: MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers.
    4. MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium.
      Title: MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium.
    5. Knockdown of lncRNA MEG8 inhibits cell proliferation and invasion, but promotes cell apoptosis in hemangioma, via miR203induced mediation of the Notch signaling pathway.
      Title: Knockdown of lncRNA MEG8 inhibits cell proliferation and invasion, but promotes cell apoptosis in hemangioma, via miR‑203‑induced mediation of the Notch signaling pathway.
    6. LncRNA MEG8 is upregulated in gestational diabetes mellitus (GDM) and predicted kidney injury.
      Title: LncRNA MEG8 is upregulated in gestational diabetes mellitus (GDM) and predicted kidney injury.
    7. LncRNA MEG8 promotes tumor progression of non-small cell lung cancer via regulating miR-107/CDK6 axis.
      Title: LncRNA MEG8 promotes tumor progression of non-small cell lung cancer via regulating miR-107/CDK6 axis.
    8. LncRNA MEG8 plays an oncogenic role in hepatocellular carcinoma progression through miR-367-3p/14-3-3zeta/TGFbetaR1 axis.
      Title: LncRNA MEG8 plays an oncogenic role in hepatocellular carcinoma progression through miR-367-3p/14-3-3ζ/TGFβR1 axis.
    9. Identification of MEG8/miR-378d/SOBP axis as a novel regulatory network and associated with immune infiltrates in ovarian carcinoma by integrated bioinformatics analysis.
      Title: Identification of MEG8/miR-378d/SOBP axis as a novel regulatory network and associated with immune infiltrates in ovarian carcinoma by integrated bioinformatics analysis.
    10. LncRNA MEG8 promotes TNF-alpha expression by sponging miR-454-3p in bone-invasive pituitary adenomas.
      Title: LncRNA MEG8 promotes TNF-α expression by sponging miR-454-3p in bone-invasive pituitary adenomas.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • RNA Imprinted and Accumulated in Nucleus
    • imprinted RNA near Meg3/Gtl2
    • lncRNA microRNA megacluster host
    • long intergenic non-protein coding RNA 24
    • maternally expressed (in Callipyge) 8
    • small nucleolar RNA host gene 23 (non-protein coding)
    • small nucleolar RNA host gene 24 (non-protein coding)

    Clone Names

    • AL132709.5, AL132709.8, DKFZp686L05266

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_045000.6 RefSeqGene

      Range
      58381..167845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1058

    RNA

    1. NR_146000.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL117190, AL132709

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      100889649..100999113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      95125076..95234524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_024149.2: Suppressed sequence

      Description
      NR_024149.2: This RefSeq was removed because it is now thought that this transcript is partial.

    2. NR_110178.1: Suppressed sequence

      Description
      NR_110178.1: This RefSeq was removed because it is now thought that this transcript is partial.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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