Kank2 KN motif and ankyrin repeat domains 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kank2provided by MGI
Official Full Name: KN motif and ankyrin repeat domains 2provided by MGI
Primary source: MGI:MGI:2384568
See related: Ensembl:ENSMUSG00000032194 AllianceGenome:MGI:2384568
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ankrd25
Summary: Involved in podocyte cell migration and regulation of Rho protein signal transduction. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in 2nd branchial arch; blastocyst; cerebral cortex; limb; and meninges. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16 and palmoplantar keratoderma and woolly hair. Orthologous to human KANK2 (KN motif and ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 63.8), lung adult (RPKM 50.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.88 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21678069..21709842, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21766773..21798546, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.
Title: Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.
Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
Title: Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
identify Kank proteins as talin activators that decrease the grip between the integrin-talin complex and actomyosin to regulate cell migration velocity
Title: Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation.
sult1b1 may be involved in the sulfonylation of podocyte protein podocalyxin, whereas ankrd25 may contribute to controlling actin dynamics in podocyte foot processes.
Title: Expression of novel podocyte-associated proteins sult1b1 and ankrd25.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236071

AI504612 (e-PCR)
- UniSTS:179866

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in kidney epithelium development	ISO Inferred from Sequence Orthology more info
involved_in kidney epithelium development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vitamin D receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vitamin D receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vitamin D receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in podocyte cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in podocyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: KN motif and ankyrin repeat domain-containing protein 2

Names: ankyrin repeat domain 25; ankyrin repeat domain-containing protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145611.4 → NP_663586.3 KN motif and ankyrin repeat domain-containing protein 2

See identical proteins and their annotated locations for NP_663586.3

Status: VALIDATED

Source sequence(s)

AC161371, AK049288, BB517655

Consensus CDS

CCDS22911.1

UniProtKB/Swiss-Prot

Q8BLD5, Q8BX02, Q91Z35

Related

ENSMUSP00000034717.6, ENSMUST00000034717.7

Conserved Domains (6) summary

cd00204
Location:653 → 784

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12075
Location:31 → 69

KN_motif; KN motif

pfam12796
Location:663 → 761

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:634 → 679

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:750 → 805

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:731 → 761

ANK; ANK repeat [structural motif]