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    Fkbp2 FK506 binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 14227, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fkbp2provided by MGI
    Official Full Name
    FK506 binding protein 2provided by MGI
    Primary source
    MGI:MGI:95542
    See related
    Ensembl:ENSMUSG00000056629 AllianceGenome:MGI:95542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mFKBP2; mFKBP13
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in central nervous system and retina. Orthologous to human FKBP2 (FKBP prolyl isomerase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 24.7), placenta adult (RPKM 23.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fkbp2 in Genome Data Viewer
    Location:
    19 A; 19 5.12 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6955105..6957832, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6977737..6980464, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene phospholipase C, beta 3 Neighboring gene predicted gene, 52400 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7050464-7050926 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14B Neighboring gene predicted gene, 51400 Neighboring gene predicted gene, 54053 Neighboring gene vascular endothelial growth factor B Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene STARR-positive B cell enhancer ABC_E1971

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rapamycin inhibits vascular smooth muscle cell migration. Poon M, et al. J Clin Invest, 1996 Nov 15. PMID 8941644, Free PMC Article
    2. Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1. Hendrickson BA, et al. Gene, 1993 Dec 8. PMID 7505249
    3. The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. Walensky LD, et al. J Cell Biol, 1998 Apr 6. PMID 9531554, Free PMC Article
    4. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
    5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP2
    Names
    13 kDa FK506-binding protein
    13 kDa FKBP
    PPIase FKBP2
    immunophilin FKBP13
    rotamase
    NP_001159840.1
    NP_001347215.1
    NP_001347217.1
    NP_032046.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166368.2 → NP_001159840.1  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

      See identical proteins and their annotated locations for NP_001159840.1

      Status: VALIDATED

      Source sequence(s)
      AC120557, CF949699, DV655383
      Consensus CDS
      CCDS29515.1
      UniProtKB/Swiss-Prot
      P45878
      UniProtKB/TrEMBL
      Q3TND1, Q3UND3
      Related
      ENSMUSP00000136438.2, ENSMUST00000177752.9
      Conserved Domains (1) summary
      pfam00254
      Location:40 → 132
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    2. NM_001360286.1 → NP_001347215.1  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC120557, CF728525
      Consensus CDS
      CCDS29515.1
      UniProtKB/Swiss-Prot
      P45878
      UniProtKB/TrEMBL
      Q3TND1, Q3UND3
      Conserved Domains (1) summary
      pfam00254
      Location:40 → 132
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    3. NM_001360288.1 → NP_001347217.1  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC120557
      Consensus CDS
      CCDS29515.1
      UniProtKB/Swiss-Prot
      P45878
      UniProtKB/TrEMBL
      Q3TND1, Q3UND3
      Conserved Domains (1) summary
      pfam00254
      Location:40 → 132
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    4. NM_008020.4 → NP_032046.1  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

      See identical proteins and their annotated locations for NP_032046.1

      Status: VALIDATED

      Source sequence(s)
      AC120557, AK144284, CF949699
      Consensus CDS
      CCDS29515.1
      UniProtKB/Swiss-Prot
      P45878
      UniProtKB/TrEMBL
      Q3TND1, Q3UND3
      Related
      ENSMUSP00000066839.9, ENSMUST00000070878.9
      Conserved Domains (1) summary
      pfam00254
      Location:40 → 132
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6955105..6957832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45878.1 GenPept UniProtKB/Swiss-Prot:P45878

    Gene LinkOut

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