Pdgfrl platelet-derived growth factor receptor-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdgfrlprovided by MGI
Official Full Name: platelet-derived growth factor receptor-likeprovided by MGI
Primary source: MGI:MGI:1916047
See related: Ensembl:ENSMUSG00000031595 AllianceGenome:MGI:1916047
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110039P19Rik
Summary: Predicted to be located in extracellular region. Is expressed in several structures, including facial prominence; physiological umbilical hernia; reproductive system; rib; and skeletal musculature. Human ortholog(s) of this gene implicated in colorectal cancer and hepatocellular carcinoma. Orthologous to human PDGFRL (platelet derived growth factor receptor like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 12.0), bladder adult (RPKM 8.7) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 23.89 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (41379270..41443819)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (40926233..40990782)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that PDGFRL plays the different roles, depending upon cell types. Particularly, in chondrocytes, PDGFRL may play a new and important role which is distinct from the function previously reported.
Title: A Tumor Suppressor Gene Product, Platelet-Derived Growth Factor Receptor-Like Protein Controls Chondrocyte Proliferation and Differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: platelet-derived growth factor receptor-like protein

Names: PDGFR-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026840.3 → NP_081116.3 platelet-derived growth factor receptor-like protein precursor

See identical proteins and their annotated locations for NP_081116.3

Status: VALIDATED

Source sequence(s)

AK132625

Consensus CDS

CCDS22259.1

UniProtKB/Swiss-Prot

Q3V182, Q6PE55, Q9D0Z1

UniProtKB/TrEMBL

A0A0R4J0C9

Related

ENSMUSP00000034004.9, ENSMUST00000034004.10

Conserved Domains (3) summary

smart00410
Location:83 → 143

IG_like; Immunoglobulin like

pfam07679
Location:272 → 373

I-set; Immunoglobulin I-set domain

cl11960
Location:293 → 372

Ig; Immunoglobulin domain