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    Mtus1 mitochondrial tumor suppressor 1 [ Mus musculus (house mouse) ]

    Gene ID: 102103, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mtus1provided by MGI
    Official Full Name
    mitochondrial tumor suppressor 1provided by MGI
    Primary source
    MGI:MGI:2142572
    See related
    Ensembl:ENSMUSG00000045636 AllianceGenome:MGI:2142572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MD44; Atip1; MTSG1; ATBP135; mKIAA1288; Cctsg1-440; B430010I23Rik; B430305I03Rik
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within regulation of macrophage chemotaxis. Located in cytoplasm. Is expressed in several structures, including extraembryonic component; eye; genitourinary system; heart; and nervous system. Orthologous to human MTUS1 (microtubule associated scaffold protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 15.8), cerebellum adult (RPKM 12.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtus1 in Genome Data Viewer
    Location:
    8 A4; 8 23.89 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41443949..41587318, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40990912..41133983, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Neighboring gene STARR-seq mESC enhancer starr_21277 Neighboring gene platelet-derived growth factor receptor-like Neighboring gene STARR-positive B cell enhancer ABC_E9310 Neighboring gene STARR-seq mESC enhancer starr_21279 Neighboring gene RIKEN cDNA B430010I23 gene Neighboring gene predicted gene 16193 Neighboring gene STARR-seq mESC enhancer starr_21283 Neighboring gene STARR-seq mESC enhancer starr_21286 Neighboring gene predicted gene, 39167 Neighboring gene STARR-seq mESC enhancer starr_21287 Neighboring gene fibrinogen-like protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Attenuation of cuff-induced neointimal formation by overexpression of angiotensin II type 2 receptor-interacting protein 1. Fujita T, et al. Hypertension, 2009 Apr. PMID 19221207
    2. Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein. Wruck CJ, et al. Arterioscler Thromb Vasc Biol, 2005 Jan. PMID 15539617
    3. Cardiovascular ATIP (Angiotensin receptor type 2 interacting protein) expression in mouse development. Bundschu K, et al. Dev Dyn, 2014 May. PMID 24288149
    4. Effect of angiotensin II type 2 receptor-interacting protein on adipose tissue function via modulation of macrophage polarization. Jing F, et al. PLoS One, 2013. PMID 23565185, Free PMC Article
    5. ATIP3, a novel prognostic marker of breast cancer patient survival, limits cancer cell migration and slows metastatic progression by regulating microtubule dynamics. Molina A, et al. Cancer Res, 2013 May 1. PMID 23396587

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. important role in AT2 receptor-mediated PPARgamma activation
      Title: Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPARγ.
    2. ATIPs seem to be mainly involved in the developmental regulation of the cardiovascular system and may act in different AT2-dependent and -independent manners.
      Title: Cardiovascular ATIP (Angiotensin receptor type 2 interacting protein) expression in mouse development.
    3. ATIP1 could exert anti-inflammatory effects in adipose tissue via macrophage polarization associated with improvement of insulin resistance.
      Title: Effect of angiotensin II type 2 receptor-interacting protein on adipose tissue function via modulation of macrophage polarization.
    4. analysis of a functional ATIP3 domain that associates with microtubules and recapitulates the effects of ATIP3 on microtubule dynamics, cell proliferation, and migration in breast cancer
      Title: ATIP3, a novel prognostic marker of breast cancer patient survival, limits cancer cell migration and slows metastatic progression by regulating microtubule dynamics.
    5. Reports the first generation of a MTUS1 KO mouse, developing spontaneous heart hypertrophy and increased cell proliferation, confirming once more the anti-proliferative effect of MTUS1, and a SLE-like lymphoproliferative disease.
      Title: Microtubule associated tumor suppressor 1 deficient mice develop spontaneous heart hypertrophy and SLE-like lymphoproliferative disease.
    6. ATIP3 is a novel microtubule-associated protein related to MTUS1, with a role in invasiveness and progression of breast neoplasms
      Title: 8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis.
    7. ATIP1 plays an important role in cuff-induced vascular remodeling in mice
      Title: Attenuation of cuff-induced neointimal formation by overexpression of angiotensin II type 2 receptor-interacting protein 1.
    8. Results identify ATIP1 (angiotensin II AT2 receptor-interacting protein) as a novel early component of growth inhibitory signaling cascade.
      Title: Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC115798

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of macrophage chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated tumor suppressor 1 homolog
    Names
    AT2 receptor-binding protein
    AT2 receptor-interacting protein 1
    angiotensin II AT2 receptor-interacting protein 1
    angiotensin-II type 2 receptor-interacting protein
    coiled-coiled tumor suppressor gene 1 protein
    coiled-coiled tumor supressor gene 1
    mitochondrial tumor suppressor 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005863.2 → NP_001005863.1  microtubule-associated tumor suppressor 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_001005863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK143781, AW990620, BC089009
      Consensus CDS
      CCDS40328.1
      UniProtKB/Swiss-Prot
      Q3UP60, Q5HZI1, Q6ITD2, Q6ZPU5, Q80YG5, Q80YV9, Q80ZZ2, Q8BH23, Q8BMM8, Q8C0C8
      UniProtKB/TrEMBL
      A0A0R4J1L9
      Related
      ENSMUSP00000059503.7, ENSMUST00000059115.13
      Conserved Domains (1) summary
      TIGR02168
      Location:855 → 1155
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001005864.3 → NP_001005864.1  microtubule-associated tumor suppressor 1 homolog isoform 3

      See identical proteins and their annotated locations for NP_001005864.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in shorter protein (isoform 3) with a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BB647317, BC043321, DV650567
      Consensus CDS
      CCDS40329.1
      UniProtKB/TrEMBL
      A0A0R4J147
      Related
      ENSMUSP00000091252.5, ENSMUST00000093534.11
      Conserved Domains (2) summary
      pfam09755
      Location:193 → 460
      DUF2046; Uncharacterized conserved protein H4 (DUF2046)
      cl19219
      Location:330 → 406
      DUF342; Protein of unknown function (DUF342)

    3. NM_001005865.4 → NP_001005865.2  microtubule-associated tumor suppressor 1 homolog isoform 4

      See identical proteins and their annotated locations for NP_001005865.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in shorter protein (isoform 4) with a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC116511
      Consensus CDS
      CCDS40330.1
      UniProtKB/TrEMBL
      A0A0R4J0N9
      Related
      ENSMUSP00000053554.8, ENSMUST00000051379.14
      Conserved Domains (1) summary
      cl19219
      Location:250 → 326
      DUF342; Protein of unknown function (DUF342)

    4. NM_001286413.2 → NP_001273342.1  microtubule-associated tumor suppressor 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_001273342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AC116511, AC156554
      Consensus CDS
      CCDS40328.1
      UniProtKB/Swiss-Prot
      Q3UP60, Q5HZI1, Q6ITD2, Q6ZPU5, Q80YG5, Q80YV9, Q80ZZ2, Q8BH23, Q8BMM8, Q8C0C8
      UniProtKB/TrEMBL
      A0A0R4J1L9
      Related
      ENSMUSP00000112626.2, ENSMUST00000118835.8
      Conserved Domains (1) summary
      TIGR02168
      Location:855 → 1155
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. NM_001403946.1 → NP_001390875.1  microtubule-associated tumor suppressor 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554
      UniProtKB/TrEMBL
      A0A0R4J1L9

    6. NM_001403947.1 → NP_001390876.1  microtubule-associated tumor suppressor 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554
      UniProtKB/TrEMBL
      A0A0R4J1L9

    7. NM_001403950.1 → NP_001390879.1  microtubule-associated tumor suppressor 1 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554

    8. NM_001403952.1 → NP_001390881.1  microtubule-associated tumor suppressor 1 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554

    9. NM_001403954.1 → NP_001390883.1  microtubule-associated tumor suppressor 1 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC116511

    10. NM_001403955.1 → NP_001390884.1  microtubule-associated tumor suppressor 1 homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC116511

    11. NM_001403956.1 → NP_001390885.1  microtubule-associated tumor suppressor 1 homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554
      UniProtKB/TrEMBL
      Q8BXV7
      Related
      ENSMUST00000142936.2

    RNA

    1. NR_175785.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      41443949..41587318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509241.4 → XP_006509304.1  microtubule-associated tumor suppressor 1 homolog isoform X4

      Conserved Domains (1) summary
      TIGR02168
      Location:98 → 417
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_036153702.1 → XP_036009595.1  microtubule-associated tumor suppressor 1 homolog isoform X3

    RNA

    1. XR_004934740.1 RNA Sequence

    2. XR_004934738.1 RNA Sequence

    3. XR_004934737.1 RNA Sequence

    4. XR_004934739.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZI1.2 GenPept UniProtKB/Swiss-Prot:Q5HZI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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