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    Ldc1 leucine decarboxylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 332942, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ldc1provided by MGI
    Official Full Name
    leucine decarboxylase 1provided by MGI
    Primary source
    MGI:MGI:2685699
    See related
    Ensembl:ENSMUSG00000023120 AllianceGenome:MGI:2685699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm853
    Summary
    Predicted to be involved in negative regulation of protein catabolic process; positive regulation of polyamine transmembrane transport; and putrescine biosynthetic process from ornithine. Predicted to be active in cytoplasm. Orthologous to human LDC1P (leucine decarboxylase 1, pseudogene). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward kidney adult (RPKM 23.2) See more
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    Genomic context

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    See Ldc1 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.43 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130102816..130116221, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130209023..130222428, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40259 Neighboring gene tubulointerstitial nephritis antigen-like 1 Neighboring gene predicted gene, 52490 Neighboring gene predicted gene, 46724 Neighboring gene serine incorporator 2 Neighboring gene predicted gene, 34957

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of an androgen-responsive, ornithine decarboxylase-related protein in mouse kidney. Silander KM, et al. Biosci Rep, 2017 Aug 31. PMID 28607032, Free PMC Article
    2. The mouse Gm853 gene encodes a novel enzyme: Leucine decarboxylase. Lambertos A, et al. Biochim Biophys Acta Gen Subj, 2018 Mar. PMID 29108956
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables ornithine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of polyamine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in putrescine biosynthetic process from ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ornithine decarboxylase-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034872.2 → NP_001030044.1  ornithine decarboxylase-like

      Status: VALIDATED

      Source sequence(s)
      AK143920
      Consensus CDS
      CCDS38890.1
      UniProtKB/TrEMBL
      A3KFW3, Q3UNZ2
      Related
      ENSMUSP00000023884.7, ENSMUST00000023884.7
      Conserved Domains (1) summary
      cd00622
      Location:50 → 410
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      130102816..130116221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503200.4 → XP_006503263.1  ornithine decarboxylase-like isoform X6

      Conserved Domains (1) summary
      cl00261
      Location:1 → 150
      PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes

    2. XM_006503193.4 → XP_006503256.1  ornithine decarboxylase-like isoform X1

      Conserved Domains (1) summary
      cd00622
      Location:50 → 382
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

    3. XM_006503195.4 → XP_006503258.1  ornithine decarboxylase-like isoform X2

      Conserved Domains (1) summary
      cd00622
      Location:50 → 382
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

    4. XM_006503197.3 → XP_006503260.1  ornithine decarboxylase-like isoform X3

      UniProtKB/TrEMBL
      A3KFW3, Q3UNZ2
      Conserved Domains (1) summary
      cd00622
      Location:50 → 410
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

    5. XM_006503196.3 → XP_006503259.1  ornithine decarboxylase-like isoform X3

      UniProtKB/TrEMBL
      A3KFW3, Q3UNZ2
      Conserved Domains (1) summary
      cd00622
      Location:50 → 410
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

    6. XM_006503198.3 → XP_006503261.1  ornithine decarboxylase-like isoform X4

      UniProtKB/TrEMBL
      B7ZWH9
      Conserved Domains (1) summary
      cd00622
      Location:50 → 382
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

    7. XM_006503199.2 → XP_006503262.1  ornithine decarboxylase-like isoform X5

      Conserved Domains (1) summary
      cd00622
      Location:50 → 262
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
    Nucleotide Protein Strain
    Heading Accession and Version

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