Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnn2provided by MGI
Official Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2provided by MGI
Primary source: MGI:MGI:2153182
See related: Ensembl:ENSMUSG00000054477 AllianceGenome:MGI:2153182
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: bc; SK2; fri; SKCA2; KCa2.2
Summary: Enables small conductance calcium-activated potassium channel activity. Involved in membrane repolarization during atrial cardiac muscle cell action potential; modulation of chemical synaptic transmission; and potassium ion transmembrane transport. Located in several cellular components, including T-tubule; Z disc; and smooth endoplasmic reticulum. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in brain; heart; and heart ventricle. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in myoclonic dystonia 34. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 77.6), cerebellum adult (RPKM 7.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B3- C; 18 24.34 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (45401754..45818954)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (45268750..45685887)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through the NF-kappaB signaling pathway.
Title: ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through the NF-κB signaling pathway.
MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice.
Title: MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice.
Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice.
Title: Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice.
PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome.
Title: PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome.
SK2 plasticity and excitability modulation are essential for specific forms of motor learning.
Title: SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.
Junctophilin 2, as junctional membrane complex (JMC) protein, is an important regulator of the cardiac SK channels
Title: Functional interaction of Junctophilin 2 with small- conductance Ca(2+) -activated potassium channel subtype 2(SK2) in mouse cardiac myocytes.
results indicate that FBXO-32 contributes to SK2 down-regulation and that the F-box domain is essential for FBXO-32 function.
Title: F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria.
SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake.
Title: SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake.
Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT) neuronal excitability.
Title: Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels.
SK2 is nuclear in primary neurons and, unexpectedly, overexpressed SK2 is neurotoxic in a dose-dependent manner.. We also found that SK2 is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease
Title: Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Associated conditions

Description	Tests
bouncy GeneReviews: Not available
frissonant GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (2)
Spontaneous (9) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU043608 (e-PCR)
- UniSTS:160741

NoName (e-PCR)
- UniSTS:237799

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables small conductance calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables small conductance calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables small conductance calcium-activated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables small conductance calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in membrane repolarization during atrial cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small conductance calcium-activated potassium channel protein 2

Names: small conductance calcium-activated potassium channel subfamily N member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001312905.2 → NP_001299834.1 small conductance calcium-activated potassium channel protein 2 isoform SK2-L

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (SK2-L).

Source sequence(s)

AC099590, AC101593, AC121957, AC122852

UniProtKB/Swiss-Prot

E9QNY5, P58390, Q3UF29, Q540U9, Q8CCH4

Conserved Domains (3) summary

pfam02888
Location:682 → 754

CaMBD; Calmodulin binding domain

pfam03530
Location:394 → 501

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:589 → 668

Ion_trans_2; Ion channel
NM_080465.2 → NP_536713.1 small conductance calcium-activated potassium channel protein 2 isoform SK2-S

See identical proteins and their annotated locations for NP_536713.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform SK2-S, which is shorter at the N-terminus, compared to isoform SK2-L.

Source sequence(s)

AC101593, AC121957

Consensus CDS

CCDS84380.1

UniProtKB/TrEMBL

A0A1B0GT12, Q8C7F3

Related

ENSMUSP00000148153.2, ENSMUST00000211323.3

Conserved Domains (3) summary

smart01053
Location:407 → 482

CaMBD; Calmodulin binding domain

pfam03530
Location:119 → 226

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:314 → 393

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

45401754..45818954

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160982.1 → XP_036016875.1 small conductance calcium-activated potassium channel protein 2 isoform X2

UniProtKB/Swiss-Prot

E9QNY5, P58390, Q3UF29, Q540U9, Q8CCH4

Conserved Domains (3) summary

smart01053
Location:672 → 750

CaMBD; Calmodulin binding domain

pfam03530
Location:384 → 491

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:579 → 658

Ion_trans_2; Ion channel
XM_030250331.2 → XP_030106191.1 small conductance calcium-activated potassium channel protein 2 isoform X1

UniProtKB/Swiss-Prot

E9QNY5, P58390, Q3UF29, Q540U9, Q8CCH4

Conserved Domains (3) summary

pfam02888
Location:682 → 757

CaMBD; Calmodulin binding domain

pfam03530
Location:394 → 501

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:589 → 668

Ion_trans_2; Ion channel
XM_036160983.1 → XP_036016876.1 small conductance calcium-activated potassium channel protein 2 isoform X3

Conserved Domains (2) summary

smart01053
Location:64 → 139

CaMBD; Calmodulin binding domain

pfam07885
Location:1 → 50

Ion_trans_2; Ion channel