Lnpep leucyl/cystinyl aminopeptidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lnpepprovided by MGI
Official Full Name: leucyl/cystinyl aminopeptidaseprovided by MGI
Primary source: MGI:MGI:2387123
See related: Ensembl:ENSMUSG00000023845 AllianceGenome:MGI:2387123
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAP; IRAP; PLAP; gp160; vp165; 2010309L07Rik; 4732490P18Rik
Summary: Enables aminopeptidase activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within protein catabolic process. Located in cytoplasmic vesicle membrane; perinuclear region of cytoplasm; and plasma membrane. Is expressed in extraembryonic component; labyrinthine zone; and placenta. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human LNPEP (leucyl and cystinyl aminopeptidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 7.9), thymus adult (RPKM 6.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.2; 17 9.77 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (17747985..17846303, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (17527723..17624489, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi.
Title: Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi.
Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress.
Title: Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress.
Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection.
Title: Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection.
Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy.
Title: Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy.
IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.
Title: IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.
IRAP, similar to Glut4 and sortilin, is retrieved from endosomes to the trans-Golgi network by retromer.
Title: Insulin-responsive amino peptidase follows the Glut4 pathway but is dispensable for the formation and translocation of insulin-responsive vesicles.
Significant role for IRAP in postnatal brain development and normal function of the hippocampus in adulthood.
Title: Forebrain neurone-specific deletion of insulin-regulated aminopeptidase causes age related deficits in memory.
this paper shows that endosomal retention of TLR9 via the interaction of IRAP with the actin cytoskeleton is a mechanism that prevents hyper-activation of TLR9 in dendritic cells
Title: IRAP(+) endosomes restrict TLR9 activation and signaling.
IRAP is more highly expressed in pro-inflammatory M1-activated macrophages.
Title: Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages.
IRAP deficiency may lead to suppression of PAI-1 expression in adipocytes and upregulation of UCP-1-mediated thermogenesis in brown adipose tissue and increased energy expenditure to prevent the development of obesity.
Title: IRAP deficiency attenuates diet-induced obesity in mice through increased energy expenditure.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in insulin-responsive compartment	ISO Inferred from Sequence Orthology more info
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucyl-cystinyl aminopeptidase

Names: OTase; cystinyl aminopeptidase; oxytocinase

NP_766415.1

EC 3.4.11.3

XP_036016480.1

EC 3.4.11.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172827.3 → NP_766415.1 leucyl-cystinyl aminopeptidase

Status: PROVISIONAL

Source sequence(s)

AC121795, AC147983

Consensus CDS

CCDS37457.1

UniProtKB/Swiss-Prot

Q8C129

Related

ENSMUSP00000036998.3, ENSMUST00000041047.4

Conserved Domains (2) summary

cd09601
Location:177 → 612

M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)

pfam11838
Location:689 → 1009

ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

17747985..17846303 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160587.1 → XP_036016480.1 leucyl-cystinyl aminopeptidase isoform X1

UniProtKB/TrEMBL

Q6NY09

Conserved Domains (1) summary

cd09601
Location:177 → 595

M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)