Clip3 CAP-GLY domain containing linker protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clip3provided by MGI
Official Full Name: CAP-GLY domain containing linker protein 3provided by MGI
Primary source: MGI:MGI:1923936
See related: Ensembl:ENSMUSG00000013921 AllianceGenome:MGI:1923936
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clipr-59; 1500005P14Rik
Summary: Predicted to enable ganglioside binding activity and microtubule plus-end binding activity. Involved in several processes, including fat cell differentiation; positive regulation of D-glucose transmembrane transport; and positive regulation of protein localization to plasma membrane. Located in plasma membrane and trans-Golgi network. Is expressed in several structures, including central nervous system; diaphragm; genitourinary system; gut; and retina layer. Orthologous to human CLIP3 (CAP-Gly domain containing linker protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 110.2), cortex adult (RPKM 66.8) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 17.37 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (29991120..30007792)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30291695..30308367)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collectively, our studies demonstrate that formation of an Elmo2.ClipR-59 complex plays an important role in myoblast fusion.
Title: ClipR-59 interacts with Elmo2 and modulates myoblast fusion.
CLIPR-59 is involved in the stabilization of specific motor axons at the neuromuscular junction during mouse late embryogenesis and its role is crucial for mouse perinatal development.
Title: CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development.
Because ClipR-59 also interacts with Akt and enhances the interaction between Akt and AS160, we suggest that ClipR-59 functions as a scaffold protein to facilitate Akt-mediated AS160 phosphorylation, thereby regulating glucose transport
Title: The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation.
ClipR-59 functions as a scaffold protein that interacts with phospho-Akt and recruits active Akt on the membrane and may play an important role in adipocyte glucose transport.
Title: ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI839550 (e-PCR)
- UniSTS:164353

CLIPR-59__4586 (e-PCR)
- UniSTS:471394

UniSTS:235641 (e-PCR)
- UniSTS:235641

AI844915 (e-PCR)
- UniSTS:165519

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ganglioside binding	ISO Inferred from Sequence Orthology more info
enables ganglioside binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fat cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in membrane biogenesis	ISO Inferred from Sequence Orthology more info
involved_in membrane biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of D-glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport along microtubule	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CAP-Gly domain-containing linker protein 3

Names: CLIP-170-related 59 kDa protein; clip-170 related protein 59 kDa; cytoplasmic linker protein 170-related 59 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081114.2 → NP_001074583.1 CAP-Gly domain-containing linker protein 3

See identical proteins and their annotated locations for NP_001074583.1

Status: VALIDATED

Source sequence(s)

AC149067

Consensus CDS

CCDS39880.1

UniProtKB/Swiss-Prot

B9EHT4, Q7TNI1, Q9DB67

Related

ENSMUSP00000014065.9, ENSMUST00000014065.16

Conserved Domains (3) summary

sd00045
Location:120 → 157

ANK; ANK repeat [structural motif]

pfam01302
Location:418 → 482

CAP_GLY; CAP-Gly domain

pfam12796
Location:122 → 228

Ank_2; Ankyrin repeats (3 copies)
NM_001360763.1 → NP_001347692.1 CAP-Gly domain-containing linker protein 3

Status: VALIDATED

Source sequence(s)

AC149067

Consensus CDS

CCDS39880.1

UniProtKB/Swiss-Prot

B9EHT4, Q7TNI1, Q9DB67

Conserved Domains (3) summary

sd00045
Location:120 → 157

ANK; ANK repeat [structural motif]

pfam01302
Location:418 → 482

CAP_GLY; CAP-Gly domain

pfam12796
Location:122 → 228

Ank_2; Ankyrin repeats (3 copies)
NM_001360764.1 → NP_001347693.1 CAP-Gly domain-containing linker protein 3

Status: VALIDATED

Source sequence(s)

AC149067

Consensus CDS

CCDS39880.1

UniProtKB/Swiss-Prot

B9EHT4, Q7TNI1, Q9DB67

Conserved Domains (3) summary

sd00045
Location:120 → 157

ANK; ANK repeat [structural motif]

pfam01302
Location:418 → 482

CAP_GLY; CAP-Gly domain

pfam12796
Location:122 → 228

Ank_2; Ankyrin repeats (3 copies)