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    Ednra endothelin receptor type A [ Mus musculus (house mouse) ]

    Gene ID: 13617, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ednraprovided by MGI
    Official Full Name
    endothelin receptor type Aprovided by MGI
    Primary source
    MGI:MGI:105923
    See related
    Ensembl:ENSMUSG00000031616 AllianceGenome:MGI:105923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ETa; ET-AR; AEA001; Gpcr10; Mhdaaea1
    Summary
    Enables endothelin receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; neural crest cell development; and regulation of D-glucose transmembrane transport. Is active in cell periphery. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and genitourinary system. Used to study mandibulofacial dysostosis with alopecia and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 16.9), limb E14.5 (RPKM 15.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ednra in Genome Data Viewer
    Location:
    8 C1; 8 36.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (78389658..78451081, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (77663029..77724452, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933431K23 gene Neighboring gene RIKEN cDNA 1700092C02 gene Neighboring gene predicted gene, 39200 Neighboring gene VISTA enhancer mm761 Neighboring gene STARR-seq mESC enhancer starr_21959 Neighboring gene predicted gene, 57485 Neighboring gene predicted gene, 39201 Neighboring gene predicted gene, 29845

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables endothelin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables endothelin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables endothelin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in artery smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in artery smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in atrial cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonogenesis involved in innervation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cAMP/PKA signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cardiac chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to follicle-stimulating hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to human chorionic gonadotropin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to human chorionic gonadotropin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to luteinizing hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cranial skeletal system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in developmental pigmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in embryonic heart tube development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in endothelin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endothelin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in endothelin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelin receptor signaling pathway involved in heart process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in enteric nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of endothelial barrier IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in face development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in face development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glomerular endothelium development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glomerular filtration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within head development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heparin metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in histamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in left ventricular cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic cell cycle process involved in oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesenchymal cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in middle ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural crest cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural crest cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neural crest cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural crest cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in noradrenergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in norepinephrine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pharyngeal arch artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in podocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in podocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in podocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT acts_upstream_of_or_within regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization to cell leading edge IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in renal albumin absorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in renal albumin absorption IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in renal albumin absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in renal sodium ion absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to acetylcholine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in specification of segmental identity, mandibular segment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in specification of segmental identity, maxillary segment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sympathetic nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sympathetic neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular associated smooth muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasoconstriction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    endothelin-1 receptor
    Names
    ET-A
    G-protein coupled receptor 10
    endothelin A receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010332.2NP_034462.1  endothelin-1 receptor precursor

      See identical proteins and their annotated locations for NP_034462.1

      Status: VALIDATED

      Source sequence(s)
      AK043210, AV351599, CN669253
      Consensus CDS
      CCDS22427.1
      UniProtKB/Swiss-Prot
      O54993, Q61614, Q91VV2
      Related
      ENSMUSP00000034029.8, ENSMUST00000034029.8
      Conserved Domains (1) summary
      pfam00001
      Location:97367
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      78389658..78451081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)