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    Ankrd10 ankyrin repeat domain 10 [ Mus musculus (house mouse) ]

    Gene ID: 102334, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ankrd10provided by MGI
    Official Full Name
    ankyrin repeat domain 10provided by MGI
    Primary source
    MGI:MGI:1921840
    See related
    Ensembl:ENSMUSG00000031508 AllianceGenome:MGI:1921840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4833425P12Rik
    Summary
    Predicted to enable chloroplast targeting sequence binding activity. Predicted to be involved in protein targeting to chloroplast. Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; branchial arch; genitourinary system; limb; and maxillary process. Orthologous to human ANKRD10 (ankyrin repeat domain 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 34.9), thymus adult (RPKM 31.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd10 in Genome Data Viewer
    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11661581..11694617, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11611581..11635926, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:11550723-11550832 Neighboring gene STARR-seq mESC enhancer starr_20716 Neighboring gene STARR-positive B cell enhancer ABC_E9718 Neighboring gene STARR-positive B cell enhancer ABC_E2856 Neighboring gene STARR-positive B cell enhancer ABC_E1101 Neighboring gene inhibitor of growth family, member 1 Neighboring gene STARR-seq mESC enhancer starr_20718 Neighboring gene STARR-positive B cell enhancer ABC_E9307 Neighboring gene STARR-seq mESC enhancer starr_20722 Neighboring gene microRNA 7238 Neighboring gene STARR-seq mESC enhancer starr_20723 Neighboring gene sperm acrosome associated 7B Neighboring gene ribosomal protein S3A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloroplast targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to chloroplast IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167967.2 → NP_001161439.1  ankyrin repeat domain-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001161439.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a distinct 3' coding region and 3' UTR, compared to variant 1. These differences result in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK031808, AK039879, AK050983
      Consensus CDS
      CCDS52479.1
      UniProtKB/TrEMBL
      Q8BG46
      Related
      ENSMUSP00000131657.2, ENSMUST00000169782.3
      Conserved Domains (3) summary
      cd00204
      Location:56 → 177
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:62 → 154
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:56 → 88
      ANK; ANK repeat [structural motif]

    2. NM_001281974.1 → NP_001268903.1  ankyrin repeat domain-containing protein 10 isoform 3

      See identical proteins and their annotated locations for NP_001268903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK050983, AK082875, AK084456, AV319211
      UniProtKB/Swiss-Prot
      Q99LW0
      UniProtKB/TrEMBL
      Q8BG46

    3. NM_001281975.1 → NP_001268904.1  ankyrin repeat domain-containing protein 10 isoform 4

      See identical proteins and their annotated locations for NP_001268904.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (4) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK050983, AK081754, AK084456, AV319211
      UniProtKB/TrEMBL
      Q8BG46

    4. NM_133971.3 → NP_598732.2  ankyrin repeat domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_598732.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform 1.
      Source sequence(s)
      AK050983, AK082875, AK084456, AV319211
      Consensus CDS
      CCDS22098.1
      UniProtKB/Swiss-Prot
      Q8BGB6, Q99LW0
      Related
      ENSMUSP00000033905.6, ENSMUST00000033905.13
      Conserved Domains (3) summary
      cd00204
      Location:56 → 177
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:62 → 154
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:56 → 88
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_030781.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences compared to variant 1, including the use of an alternate promoter. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AK014768, AK039879

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      11661581..11694617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508685.5 → XP_006508748.1  ankyrin repeat domain-containing protein 10 isoform X1

      Conserved Domains (2) summary
      COG0666
      Location:46 → 188
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:56 → 88
      ANK; ANK repeat [structural motif]

    2. XM_006508686.5 → XP_006508749.1  ankyrin repeat domain-containing protein 10 isoform X2

      Conserved Domains (2) summary
      sd00045
      Location:19 → 48
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:23 → 105
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_006508691.5 → XP_006508754.1  ankyrin repeat domain-containing protein 10 isoform X7

      See identical proteins and their annotated locations for XP_006508754.1

    4. XM_006508688.5 → XP_006508751.1  ankyrin repeat domain-containing protein 10 isoform X5

    5. XM_030243218.2 → XP_030099078.1  ankyrin repeat domain-containing protein 10 isoform X3

      Conserved Domains (2) summary
      sd00045
      Location:19 → 48
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:23 → 105
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_030243222.2 → XP_030099082.1  ankyrin repeat domain-containing protein 10 isoform X8

    7. XM_030243221.2 → XP_030099081.1  ankyrin repeat domain-containing protein 10 isoform X6

    8. XM_036153709.1 → XP_036009602.1  ankyrin repeat domain-containing protein 10 isoform X8

    9. XM_006508687.5 → XP_006508750.1  ankyrin repeat domain-containing protein 10 isoform X4

      Conserved Domains (2) summary
      COG0666
      Location:46 → 188
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:56 → 88
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LW0.2 GenPept UniProtKB/Swiss-Prot:Q99LW0

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