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    Atp8a1 ATPase phospholipid transporting 8A1 [ Mus musculus (house mouse) ]

    Gene ID: 11980, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atp8a1provided by MGI
    Official Full Name
    ATPase phospholipid transporting 8A1provided by MGI
    Primary source
    MGI:MGI:1330848
    See related
    Ensembl:ENSMUSG00000037685 AllianceGenome:MGI:1330848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APLT; Atp3a2; ClassI; B230107D19Rik
    Summary
    Enables phosphatidylserine flippase activity. Involved in several processes, including learning; regulation of membrane lipid distribution; and synaptic vesicle endocytosis. Located in cytoplasmic vesicle and organelle membrane. Is active in glutamatergic synapse and synaptic vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ATP8A1 (ATPase phospholipid transporting 8A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 16.4), cortex adult (RPKM 15.1) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp8a1 in Genome Data Viewer
    Location:
    5 C3.1; 5 36.15 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (67775482..68004822, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (67618139..67847484, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C330024D21 gene Neighboring gene CRISPRi-validated cis-regulatory element for Bend4 and Bendr Neighboring gene STARR-seq mESC enhancer starr_13319 Neighboring gene STARR-seq mESC enhancer starr_13320 Neighboring gene STARR-seq mESC enhancer starr_13321 Neighboring gene shisa family member 3 Neighboring gene predicted gene 15478 Neighboring gene predicted gene, 46914 Neighboring gene STARR-positive B cell enhancer ABC_E1052 Neighboring gene predicted gene, 52816 Neighboring gene predicted gene 15477 Neighboring gene RIKEN cDNA 4930425K10 gene Neighboring gene predicted gene 5108

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4233

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylserine flippase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatidylserine flippase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine flippase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylserine floppase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in aminophospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aminophospholipid translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phospholipid translocation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromaffin granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phospholipid-translocating ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phospholipid-transporting ATPase IA
    Names
    ATPase 8A1, aminophospholipid transporter (APLT), class I
    ATPase 8A1, p type
    ATPase class I type 8A member 1
    ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
    P4-ATPase flippase complex alpha subunit ATP8A1
    chromaffin granule ATPase II
    probable phospholipid-transporting ATPase IA
    NP_001034088.1
    NP_001271274.1
    NP_033857.1
    XP_006503766.1
    XP_011239000.1
    XP_017176112.1
    XP_017176113.1
    XP_036020643.1
    XP_036020644.1
    XP_036020645.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038999.2NP_001034088.1  phospholipid-transporting ATPase IA isoform a

      See identical proteins and their annotated locations for NP_001034088.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform a.
      Source sequence(s)
      AC123662, AK045367, AK151709, BC094235
      Consensus CDS
      CCDS39104.1
      UniProtKB/Swiss-Prot
      P70704, Q8BR88
      UniProtKB/TrEMBL
      A1L332
      Related
      ENSMUSP00000042215.9, ENSMUST00000037380.15
      Conserved Domains (6) summary
      TIGR01652
      Location:491086
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:106191
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:486581
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:38100
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8271079
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:796825
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    2. NM_001284345.1NP_001271274.1  phospholipid-transporting ATPase IA isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon and contains a different alternate exon in the 5' coding region, compared to variant 1. It encodes isoform c, which is of the same size but lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC123662, AK045367, AK141559, AK151709, BC094235
      Consensus CDS
      CCDS80295.1
      UniProtKB/TrEMBL
      A0A0M3HEP7, A1L332
      Related
      ENSMUSP00000072738.8, ENSMUST00000072971.13
      Conserved Domains (6) summary
      TIGR01652
      Location:491086
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:106191
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:486581
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:38100
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8271079
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:796825
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    3. NM_009727.3NP_033857.1  phospholipid-transporting ATPase IA isoform b

      See identical proteins and their annotated locations for NP_033857.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon and lacks two other alternate exons in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      AC123662, AK039919, AK045367, AK141559, AK151709, BC094235
      Consensus CDS
      CCDS39105.1
      UniProtKB/TrEMBL
      A1L332
      Related
      ENSMUSP00000118379.3, ENSMUST00000135930.8
      Conserved Domains (6) summary
      TIGR01652
      Location:491071
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:106191
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:471566
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:38100
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8121064
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:781810
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      67775482..68004822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503703.5XP_006503766.1  phospholipid-transporting ATPase IA isoform X5

      See identical proteins and their annotated locations for XP_006503766.1

      UniProtKB/TrEMBL
      A1L332
      Conserved Domains (1) summary
      TIGR01652
      Location:11922
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    2. XM_036164750.1XP_036020643.1  phospholipid-transporting ATPase IA isoform X4

      UniProtKB/TrEMBL
      A1L332
      Conserved Domains (1) summary
      TIGR01652
      Location:491071
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    3. XM_011240698.4XP_011239000.1  phospholipid-transporting ATPase IA isoform X3

      UniProtKB/TrEMBL
      A1L332
      Conserved Domains (1) summary
      TIGR01652
      Location:491096
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    4. XM_036164751.1XP_036020644.1  phospholipid-transporting ATPase IA isoform X6

      UniProtKB/TrEMBL
      A1L332
      Conserved Domains (1) summary
      TIGR01652
      Location:1907
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    5. XM_017320623.3XP_017176112.1  phospholipid-transporting ATPase IA isoform X1

      UniProtKB/TrEMBL
      A1L332
      Conserved Domains (1) summary
      TIGR01652
      Location:621099
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    6. XM_017320624.3XP_017176113.1  phospholipid-transporting ATPase IA isoform X2

      UniProtKB/TrEMBL
      A1L332
      Conserved Domains (1) summary
      TIGR01652
      Location:621084
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    7. XM_036164752.1XP_036020645.1  phospholipid-transporting ATPase IA isoform X7

      UniProtKB/TrEMBL
      Q52KQ7
      Conserved Domains (1) summary
      TIGR01652
      Location:1707
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase