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    Stx7 syntaxin 7 [ Mus musculus (house mouse) ]

    Gene ID: 53331, updated on 3-Dec-2024

    Summary

    Official Symbol
    Stx7provided by MGI
    Official Full Name
    syntaxin 7provided by MGI
    Primary source
    MGI:MGI:1858210
    See related
    Ensembl:ENSMUSG00000019998 AllianceGenome:MGI:1858210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Syn7
    Summary
    Predicted to enable SNAP receptor activity; chloride channel inhibitor activity; and syntaxin binding activity. Involved in synaptic vesicle to endosome fusion. Located in endosome and perinuclear region of cytoplasm. Is active in synaptic vesicle membrane. Is expressed in central nervous system; embryonic visceral endoderm; ganglia; and neural retina. Orthologous to human STX7 (syntaxin 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 57.7), placenta adult (RPKM 42.7) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Stx7 in Genome Data Viewer
    Location:
    10 A4; 10 11.45 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (24025182..24064859)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (24149289..24188961)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26061 Neighboring gene STARR-positive B cell enhancer mm9_chr10:23851315-23851616 Neighboring gene STARR-seq mESC enhancer starr_26062 Neighboring gene STARR-positive B cell enhancer ABC_E6825 Neighboring gene trace amine-associated receptor 9 Neighboring gene predicted gene, 40614 Neighboring gene STARR-seq mESC enhancer starr_26066 Neighboring gene STARR-seq mESC enhancer starr_26067 Neighboring gene STARR-seq mESC enhancer starr_26068 Neighboring gene monooxygenase, DBH-like 1 Neighboring gene STARR-seq mESC enhancer starr_26070 Neighboring gene STARR-seq mESC enhancer starr_26072 Neighboring gene predicted gene 15270 Neighboring gene STARR-seq mESC enhancer starr_26075 Neighboring gene predicted gene, 40615

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables chloride channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organelle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organelle localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle to endosome fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle to endosome fusion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in synaptic vesicle to endosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in azurophil granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tertiary granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358563.2NP_001345492.1  syntaxin-7

      Status: VALIDATED

      Source sequence(s)
      AC125010
      Consensus CDS
      CCDS23749.1
      UniProtKB/Swiss-Prot
      O70439
      UniProtKB/TrEMBL
      Q8BH40
      Related
      ENSMUSP00000151638.2, ENSMUST00000220041.2
      Conserved Domains (2) summary
      cd00179
      Location:13150
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15875
      Location:168227
      SNARE_syntaxin7; SNARE motif of syntaxin 7
    2. NM_001428950.1NP_001415879.1  syntaxin-7

      Status: VALIDATED

      Source sequence(s)
      AC125010
      UniProtKB/Swiss-Prot
      O70439
      UniProtKB/TrEMBL
      Q8BH40
    3. NM_016797.6NP_058077.2  syntaxin-7

      See identical proteins and their annotated locations for NP_058077.2

      Status: VALIDATED

      Source sequence(s)
      AC125010
      Consensus CDS
      CCDS23749.1
      UniProtKB/Swiss-Prot
      O70439
      UniProtKB/TrEMBL
      Q8BH40
      Related
      ENSMUSP00000020174.6, ENSMUST00000020174.7
      Conserved Domains (2) summary
      cd00179
      Location:13150
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15875
      Location:168227
      SNARE_syntaxin7; SNARE motif of syntaxin 7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      24025182..24064859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512801.5XP_006512864.1  syntaxin-7 isoform X1

      Conserved Domains (2) summary
      cd00179
      Location:13150
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15875
      Location:168227
      SNARE_syntaxin7; SNARE motif of syntaxin 7