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    Rims3 regulating synaptic membrane exocytosis 3 [ Mus musculus (house mouse) ]

    Gene ID: 242662, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rims3provided by MGI
    Official Full Name
    regulating synaptic membrane exocytosis 3provided by MGI
    Primary source
    MGI:MGI:2443331
    See related
    Ensembl:ENSMUSG00000032890 AllianceGenome:MGI:2443331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nim3; Rim3; mKIAA0237; A730060M23Rik
    Summary
    Enables transmembrane transporter binding activity. Acts upstream of or within regulation of membrane potential. Predicted to be located in membrane and synapse. Predicted to be active in several cellular components, including postsynaptic cytosol; presynaptic active zone cytoplasmic component; and presynaptic membrane. Is expressed in adrenal gland; brain; and male reproductive gland or organ. Orthologous to human RIMS3 (regulating synaptic membrane exocytosis 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 28.5), cortex adult (RPKM 24.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Rims3 in Genome Data Viewer
    Location:
    4 D2.1; 4 56.58 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120711976..120753777)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120854779..120896580)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene nuclear transcription factor-Y gamma Neighboring gene microRNA 30c-1 Neighboring gene microRNA 30e Neighboring gene microRNA 30f Neighboring gene STARR-seq mESC enhancer starr_11254 Neighboring gene STARR-positive B cell enhancer ABC_E3507 Neighboring gene STARR-seq mESC enhancer starr_11255 Neighboring gene STARR-seq mESC enhancer starr_11256 Neighboring gene STARR-positive B cell enhancer mm9_chr4:120523542-120523843 Neighboring gene STARR-positive B cell enhancer ABC_E4657 Neighboring gene STARR-positive B cell enhancer ABC_E4658 Neighboring gene 60S ribosomal protein L26-like 1 pseudogene Neighboring gene predicted gene, 24678

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium-ion regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-ion regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in synaptic vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    regulating synaptic membrane exocytosis protein 3
    Names
    RIM3 gamma
    rab-3-interacting molecule 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430102.1NP_001417031.1  regulating synaptic membrane exocytosis protein 3

      Status: VALIDATED

      Source sequence(s)
      AL606904
      UniProtKB/Swiss-Prot
      Q80U57
      UniProtKB/TrEMBL
      Q14BY7
    2. NM_182929.4NP_891559.1  regulating synaptic membrane exocytosis protein 3

      See identical proteins and their annotated locations for NP_891559.1

      Status: VALIDATED

      Source sequence(s)
      AL606904
      Consensus CDS
      CCDS18595.1
      UniProtKB/Swiss-Prot
      Q80U57
      UniProtKB/TrEMBL
      Q14BY7
      Related
      ENSMUSP00000068178.3, ENSMUST00000071093.9
      Conserved Domains (1) summary
      cl14603
      Location:140285
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      120711976..120753777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503102.1XP_006503165.1  regulating synaptic membrane exocytosis protein 3 isoform X1

      Related
      ENSMUSP00000101890.2, ENSMUST00000106283.8
      Conserved Domains (1) summary
      cl14603
      Location:140285
      C2; C2 domain