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    Cpsf3 cleavage and polyadenylation specificity factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 54451, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cpsf3provided by MGI
    Official Full Name
    cleavage and polyadenylation specificity factor 3provided by MGI
    Primary source
    MGI:MGI:1859328
    See related
    Ensembl:ENSMUSG00000054309 AllianceGenome:MGI:1859328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables 5'-3' RNA exonuclease activity; RNA binding activity; and RNA endonuclease activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF3 (cleavage and polyadenylation specific factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 20.1), CNS E14 (RPKM 16.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cpsf3 in Genome Data Viewer
    Location:
    12 A1.3; 12 8.3 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (21336298..21365057)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (21286273..21315056)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene predicted gene, 40855 Neighboring gene integrin beta 1 binding protein 1 Neighboring gene predicted gene, 25821 Neighboring gene STARR-positive B cell enhancer ABC_E1152 Neighboring gene a disintegrin and metallopeptidase domain 17 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog Neighboring gene predicted gene, 22766

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC118660

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 5'-3' RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cleavage and polyadenylation specificity factor subunit 3
    Names
    CPSF 73 kDa subunit
    cleavage and polyadenylation specificity factor 73 kDa subunit
    mRNA 3'-end-processing endonuclease CPSF-73

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364372.1NP_001351301.1  cleavage and polyadenylation specificity factor subunit 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156032
      UniProtKB/TrEMBL
      Q3U057, Q3UDS1
      Conserved Domains (2) summary
      COG1236
      Location:2334
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam11718
      Location:359562
      CPSF73-100_C; Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
    2. NM_001364373.1NP_001351302.1  cleavage and polyadenylation specificity factor subunit 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156032
      Consensus CDS
      CCDS88318.1
      UniProtKB/TrEMBL
      A0A1Y7VLY3, Q497G2
      Related
      ENSMUSP00000152703.2, ENSMUST00000222968.2
      Conserved Domains (2) summary
      COG1236
      Location:14454
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      cd16292
      Location:12205
      CPSF3-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; MBL-fold metallo-hydrolase domain
    3. NM_018813.3NP_061283.2  cleavage and polyadenylation specificity factor subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_061283.2

      Status: VALIDATED

      Source sequence(s)
      AK149953, AK158036, BY094575, CF725936
      Consensus CDS
      CCDS25834.1
      UniProtKB/Swiss-Prot
      Q8CIM0, Q9QXK7
      UniProtKB/TrEMBL
      Q3U057, Q3UDS1
      Related
      ENSMUSP00000068148.9, ENSMUST00000067284.10
      Conserved Domains (3) summary
      COG1236
      Location:14454
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      cd16292
      Location:12205
      CPSF3-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; MBL-fold metallo-hydrolase domain
      pfam11718
      Location:479682
      CPSF73-100_C; Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term

    RNA

    1. NR_186677.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156032

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      21336298..21365057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515158.5XP_006515221.1  cleavage and polyadenylation specificity factor subunit 3 isoform X2

      UniProtKB/TrEMBL
      Q3U057, Q3UDS1
      Conserved Domains (2) summary
      COG1236
      Location:1417
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam11718
      Location:442645
      CPSF73-100_C; Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
    2. XM_017315136.3XP_017170625.1  cleavage and polyadenylation specificity factor subunit 3 isoform X1

      UniProtKB/TrEMBL
      Q3U057, Q3UDS1
      Conserved Domains (2) summary
      COG1236
      Location:12448
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam11718
      Location:473676
      CPSF73-100_C; Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term