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    Arnt2 aryl hydrocarbon receptor nuclear translocator 2 [ Mus musculus (house mouse) ]

    Gene ID: 11864, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arnt2provided by MGI
    Official Full Name
    aryl hydrocarbon receptor nuclear translocator 2provided by MGI
    Primary source
    MGI:MGI:107188
    See related
    Ensembl:ENSMUSG00000015709 AllianceGenome:MGI:107188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hif-2b; bHLHe1; mKIAA0307
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; aryl hydrocarbon receptor binding activity; and protein heterodimerization activity. Involved in central nervous system development; in utero embryonic development; and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ARNT2 (aryl hydrocarbon receptor nuclear translocator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 45.1), CNS E18 (RPKM 38.6) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arnt2 in Genome Data Viewer
    Location:
    7 D3; 7 48.35 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (83895486..84059201, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (84246274..84411741, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26708 Neighboring gene predicted gene, 53174 Neighboring gene STARR-seq mESC enhancer starr_19430 Neighboring gene STARR-seq mESC enhancer starr_19431 Neighboring gene predicted gene, 22177 Neighboring gene STARR-seq mESC enhancer starr_19433 Neighboring gene predicted gene 44827 Neighboring gene predicted gene, 53173 Neighboring gene STARR-seq mESC enhancer starr_19435 Neighboring gene predicted gene, 25790 Neighboring gene predicted gene, 30873 Neighboring gene STARR-seq mESC enhancer starr_19437 Neighboring gene predicted gene, 39045 Neighboring gene predicted gene, 31284

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aryl hydrocarbon receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in in utero embryonic development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to toxic substance TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to xenobiotic stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of aryl hydrocarbon receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    aryl hydrocarbon receptor nuclear translocator 2
    Names
    ARNT protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411920.1NP_001398849.1  aryl hydrocarbon receptor nuclear translocator 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC101659, AC101776
    2. NM_001411921.1NP_001398850.1  aryl hydrocarbon receptor nuclear translocator 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC101659, AC101776
    3. NM_001411922.1NP_001398851.1  aryl hydrocarbon receptor nuclear translocator 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC101659, AC101776
    4. NM_001411923.1NP_001398852.1  aryl hydrocarbon receptor nuclear translocator 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC101659, AC101776
      Related
      ENSMUSP00000146413.2, ENSMUST00000208232.2
    5. NM_001411924.1NP_001398853.1  aryl hydrocarbon receptor nuclear translocator 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC101659, AC101776
    6. NM_001411925.1NP_001398854.1  aryl hydrocarbon receptor nuclear translocator 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC101659, AC101776
    7. NM_007488.4NP_031514.3  aryl hydrocarbon receptor nuclear translocator 2 isoform a

      See identical proteins and their annotated locations for NP_031514.3

      Status: VALIDATED

      Source sequence(s)
      AC101659, AC101776
      Consensus CDS
      CCDS59733.1
      UniProtKB/Swiss-Prot
      Q61324, Q7TQG2, Q8CHG9
      Related
      ENSMUSP00000082154.4, ENSMUST00000085077.5
      Conserved Domains (3) summary
      pfam00989
      Location:137243
      PAS; PAS fold
      pfam14598
      Location:336436
      PAS_11; PAS domain
      cd18947
      Location:62124
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      83895486..84059201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152603.1XP_036008496.1  aryl hydrocarbon receptor nuclear translocator 2 isoform X3

      Conserved Domains (3) summary
      cd18947
      Location:51113
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
      pfam00989
      Location:126232
      PAS; PAS fold
      pfam14598
      Location:325425
      PAS_11; PAS domain
    2. XM_036152601.1XP_036008494.1  aryl hydrocarbon receptor nuclear translocator 2 isoform X3

      Conserved Domains (3) summary
      cd18947
      Location:51113
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
      pfam00989
      Location:126232
      PAS; PAS fold
      pfam14598
      Location:325425
      PAS_11; PAS domain
    3. XM_036152600.1XP_036008493.1  aryl hydrocarbon receptor nuclear translocator 2 isoform X3

      Conserved Domains (3) summary
      cd18947
      Location:51113
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
      pfam00989
      Location:126232
      PAS; PAS fold
      pfam14598
      Location:325425
      PAS_11; PAS domain
    4. XM_006507238.4XP_006507301.1  aryl hydrocarbon receptor nuclear translocator 2 isoform X1

      Conserved Domains (3) summary
      pfam00989
      Location:137243
      PAS; PAS fold
      pfam14598
      Location:336436
      PAS_11; PAS domain
      cd18947
      Location:62124
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
    5. XM_030242017.2XP_030097877.1  aryl hydrocarbon receptor nuclear translocator 2 isoform X3

      Related
      ENSMUSP00000147129.2, ENSMUST00000209133.2
      Conserved Domains (3) summary
      cd18947
      Location:51113
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
      pfam00989
      Location:126232
      PAS; PAS fold
      pfam14598
      Location:325425
      PAS_11; PAS domain
    6. XM_036152602.1XP_036008495.1  aryl hydrocarbon receptor nuclear translocator 2 isoform X3

      Conserved Domains (3) summary
      cd18947
      Location:51113
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
      pfam00989
      Location:126232
      PAS; PAS fold
      pfam14598
      Location:325425
      PAS_11; PAS domain
    7. XM_006507243.2XP_006507306.1  aryl hydrocarbon receptor nuclear translocator 2 isoform X4

      Conserved Domains (3) summary
      pfam00989
      Location:122228
      PAS; PAS fold
      pfam14598
      Location:321421
      PAS_11; PAS domain
      cl00081
      Location:54109
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily