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    Entpd8 ectonucleoside triphosphate diphosphohydrolase 8 [ Mus musculus (house mouse) ]

    Gene ID: 72090, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Entpd8provided by MGI
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 8provided by MGI
    Primary source
    MGI:MGI:1919340
    See related
    Ensembl:ENSMUSG00000036813 AllianceGenome:MGI:1919340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables nucleoside diphosphate phosphatase activity and ribonucleoside triphosphate phosphatase activity. Acts upstream of or within nucleoside diphosphate biosynthetic process and nucleoside monophosphate biosynthetic process. Located in membrane. Is expressed in esophagus; intestine; lung; and reproductive system. Orthologous to human ENTPD8 (ectonucleoside triphosphate diphosphohydrolase 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 99.7), small intestine adult (RPKM 77.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Entpd8 in Genome Data Viewer
    Location:
    2 A3; 2 16.97 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24969308..24975731)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25079296..25085719)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor Neighboring gene microRNA 7664 Neighboring gene STARR-seq mESC enhancer starr_03956 Neighboring gene predicted gene, 39770 Neighboring gene NADPH oxidase activator 1 Neighboring gene STARR-seq mESC enhancer starr_03957 Neighboring gene VISTA enhancer mm1454 Neighboring gene predicted gene 13387 Neighboring gene Notch-regulated ankyrin repeat protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells. Tani H, et al. Proc Natl Acad Sci U S A, 2021 Sep 28. PMID 34548395, Free PMC Article
    2. NTPDase8 protects mice from intestinal inflammation by limiting P2Y(6) receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD. Salem M, et al. Gut, 2022 Jan. PMID 33452178
    3. Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8. Bigonnesse F, et al. Biochemistry, 2004 May 11. PMID 15122917
    4. Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8. Fausther M, et al. Am J Physiol Gastrointest Liver Physiol, 2007 Mar. PMID 17095758, Free PMC Article
    5. Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. Kukulski F, et al. Purinergic Signal, 2005 Jun. PMID 18404504, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD.
      Title: NTPDase8 protects mice from intestinal inflammation by limiting P2Y(6) receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD.
    2. The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells.
      Title: The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells.
    3. Enzymatic properties of NTPDase8 (Entpd8) differ from those of other NTPDases and suggest an alternative way to modulate nucleotide levels and consequently P2Y and P2X receptor activation.
      Title: Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables apyrase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleoside diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleoside diphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nucleoside monophosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 8
    Names
    E-NTPDase 8
    NTPDase 8
    NTPDase8
    NP_082369.1
    XP_011237493.1
    XP_030107962.1
    XP_030107963.1
    XP_030107964.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028093.1 → NP_082369.1  ectonucleoside triphosphate diphosphohydrolase 8

      See identical proteins and their annotated locations for NP_082369.1

      Status: VALIDATED

      Source sequence(s)
      AV026718, AY364442, BB610017
      Consensus CDS
      CCDS15748.1
      UniProtKB/Swiss-Prot
      A2AJ99, Q6UQ22, Q8K0L2
      Related
      ENSMUSP00000110022.3, ENSMUST00000114380.9
      Conserved Domains (1) summary
      cl17037
      Location:34 → 459
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24969308..24975731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239191.2 → XP_011237493.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1

      Conserved Domains (1) summary
      cl17037
      Location:34 → 347
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. XM_030252103.2 → XP_030107963.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X3

      Related
      ENSMUST00000152326.8
      Conserved Domains (1) summary
      cl17037
      Location:3 → 262
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. XM_030252104.2 → XP_030107964.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X4

      Conserved Domains (1) summary
      cl17037
      Location:34 → 261
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. XM_030252102.2 → XP_030107962.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X2

      Conserved Domains (1) summary
      cl17037
      Location:1 → 332
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0L2.3 GenPept UniProtKB/Swiss-Prot:Q8K0L2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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