Cdc7 cell division cycle 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc7provided by MGI
Official Full Name: cell division cycle 7provided by MGI
Primary source: MGI:MGI:1309511
See related: Ensembl:ENSMUSG00000029283 AllianceGenome:MGI:1309511
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdc7l1; muCdc7
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including cell cycle phase transition; double-strand break repair via break-induced replication; and positive regulation of cell cycle process. Predicted to be located in intercellular bridge; mitotic spindle; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including gut; hemolymphoid system gland; musculature; nervous system; and sensory organ. Orthologous to human CDC7 (cell division cycle 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 17.6), limb E14.5 (RPKM 17.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 51.43 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (107112201..107132298)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (106964315..106984440)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdc7 kinase is required for postnatal brain development.
Title: Cdc7 kinase is required for postnatal brain development.
CDC7-independent G1/S transition revealed by targeted protein degradation.
Title: CDC7-independent G1/S transition revealed by targeted protein degradation.
Results suggest a new role of Claspin in initiation of DNA replication during normal S phase through the recruitment of Cdc7 that facilitates phosphorylation of Mcm proteins.
Title: Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells.
Increased Cdc7-dependent replication initiation is a hallmark of p53 gain-of function mutations in lung adenocarcinoma.
Title: p53 gain-of-function mutations increase Cdc7-dependent replication initiation.
Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity
Title: Cell division cycle 7 mediates transforming growth factor-β-induced smooth muscle maturation through activation of myocardin gene transcription.
Cdc7 mediates SMC differentiation through a mechanism distinct from cell proliferation.
Title: Cell division cycle 7 is a novel regulator of transforming growth factor-β-induced smooth muscle cell differentiation.
MCM4 phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 on chromatin
Title: Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in cell cycle phase transition	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via break-induced replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear cell cycle DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nuclear cell cycle DNA replication	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell division cycle 7-related protein kinase

Names: CDC7-related kinase; cell division cycle 7-like 1

NP_001258495.1

EC 2.7.11.1

NP_001258496.1

EC 2.7.11.1

NP_001258497.1

EC 2.7.11.1

NP_001407653.1

EC 2.7.11.1

NP_001407654.1

EC 2.7.11.1

NP_001407655.1

EC 2.7.11.1

NP_033993.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271566.2 → NP_001258495.1 cell division cycle 7-related protein kinase isoform 1

See identical proteins and their annotated locations for NP_001258495.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AC134409

Consensus CDS

CCDS19498.1

UniProtKB/Swiss-Prot

Q9WUV1, Q9Z0H0, Q9Z2Y7

Related

ENSMUSP00000113385.2, ENSMUST00000118261.8

Conserved Domains (2) summary

cd14019
Location:50 → 429

STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

cl21453
Location:337 → 559

PKc_like; Protein Kinases, catalytic domain
NM_001271567.2 → NP_001258496.1 cell division cycle 7-related protein kinase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform (1).

Source sequence(s)

AC134409

Consensus CDS

CCDS71628.1

UniProtKB/Swiss-Prot

Q9Z0H0

Related

ENSMUSP00000112392.3, ENSMUST00000117196.9

Conserved Domains (2) summary

cd14019
Location:50 → 397

STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

cl21453
Location:305 → 527

PKc_like; Protein Kinases, catalytic domain
NM_001271568.2 → NP_001258497.1 cell division cycle 7-related protein kinase isoform 3

See identical proteins and their annotated locations for NP_001258497.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks an alternate in-frame exon and uses an alternate in-frame acceptor splice site in the coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform (1).

Source sequence(s)

AC134409

Consensus CDS

CCDS71629.1

UniProtKB/TrEMBL

Q66JY4

Related

ENSMUSP00000075792.7, ENSMUST00000076467.13

Conserved Domains (1) summary

cd14019
Location:50 → 390

STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
NM_001420724.1 → NP_001407653.1 cell division cycle 7-related protein kinase isoform 2

Status: VALIDATED

Source sequence(s)

AC134409
NM_001420725.1 → NP_001407654.1 cell division cycle 7-related protein kinase isoform 4

Status: VALIDATED

Source sequence(s)

AC134409
NM_001420726.1 → NP_001407655.1 cell division cycle 7-related protein kinase isoform 5

Status: VALIDATED

Source sequence(s)

AC134409
NM_009863.4 → NP_033993.2 cell division cycle 7-related protein kinase isoform 1

See identical proteins and their annotated locations for NP_033993.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AC134409

Consensus CDS

CCDS19498.1

UniProtKB/Swiss-Prot

Q9WUV1, Q9Z0H0, Q9Z2Y7

Related

ENSMUSP00000031221.6, ENSMUST00000031221.12

Conserved Domains (2) summary

cd14019
Location:50 → 429

STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

cl21453
Location:337 → 559

PKc_like; Protein Kinases, catalytic domain