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    Pomk protein-O-mannose kinase [ Mus musculus (house mouse) ]

    Gene ID: 74653, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pomkprovided by MGI
    Official Full Name
    protein-O-mannose kinaseprovided by MGI
    Primary source
    MGI:MGI:1921903
    See related
    Ensembl:ENSMUSG00000037251 AllianceGenome:MGI:1921903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sgk196; 4930444A02Rik
    Summary
    Enables carbohydrate kinase activity. Involved in protein O-linked glycosylation. Acts upstream of or within several processes, including learning or memory; neuromuscular process; and sensory perception of pain. Is active in endoplasmic reticulum membrane. Is expressed in cerebral cortex. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A12 and muscular dystrophy-dystroglycanopathy type C12. Orthologous to human POMK (protein O-mannose kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 5.9), bladder adult (RPKM 5.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pomk in Genome Data Viewer
    Location:
    8 A2; 8 14.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26470632..26484149, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25980604..25994121, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20986 Neighboring gene potassium channel, subfamily U, member 1 Neighboring gene STARR-seq mESC enhancer starr_20989 Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene predicted gene, 31402 Neighboring gene STARR-seq mESC enhancer starr_20994 Neighboring gene farnesyltransferase, CAAX box, alpha Neighboring gene hook microtubule tethering protein 3 Neighboring gene STARR-seq mESC enhancer starr_20995 Neighboring gene STARR-seq mESC enhancer starr_20996 Neighboring gene RIKEN cDNA 1700047A11 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbohydrate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphotransferase activity, alcohol group as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphotransferase activity, alcohol group as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotransferase activity, alcohol group as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in carbohydrate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carbohydrate phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein O-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein O-mannose kinase
    Names
    probable inactive protein kinase-like protein SgK196
    sugen kinase 196
    NP_083313.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029037.4NP_083313.1  protein O-mannose kinase

      See identical proteins and their annotated locations for NP_083313.1

      Status: VALIDATED

      Source sequence(s)
      AC093366
      Consensus CDS
      CCDS22204.1
      UniProtKB/Swiss-Prot
      Q3TBZ0, Q3TUA9, Q8BZ83, Q8R2S2, Q9D5G4
      Related
      ENSMUSP00000053802.4, ENSMUST00000061850.5
      Conserved Domains (1) summary
      cl21453
      Location:80192
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      26470632..26484149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)