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    Kcnu1 potassium channel, subfamily U, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 16532, updated on 27-Nov-2024

    Summary

    Official Symbol
    Kcnu1provided by MGI
    Official Full Name
    potassium channel, subfamily U, member 1provided by MGI
    Primary source
    MGI:MGI:1202300
    See related
    Ensembl:ENSMUSG00000031576 AllianceGenome:MGI:1202300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slo3; mSlo3; Kcnma3
    Summary
    Enables potassium channel activity. Involved in fertilization and potassium ion transport. Acts upstream of or within establishment of localization in cell and protein stabilization. Located in plasma membrane. Is expressed in germ cell of testis. Human ortholog(s) of this gene implicated in spermatogenic failure 79. Orthologous to human KCNU1 (potassium calcium-activated channel subfamily U member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 17.3) and CNS E18 (RPKM 1.2) See more
    Orthologs
    NEW
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    Genomic context

    See Kcnu1 in Genome Data Viewer
    Location:
    8 A2; 8 14.17 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26338656..26427971)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25848627..25937943)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Star 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_20984 Neighboring gene steroidogenic acute regulatory protein Neighboring gene ASH2 like histone lysine methyltransferase complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E9309 Neighboring gene STARR-seq mESC enhancer starr_20986 Neighboring gene STARR-seq mESC enhancer starr_20989 Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene protein-O-mannose kinase Neighboring gene predicted gene, 31402

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables large conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reproductive process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reproductive process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    potassium channel subfamily U member 1
    Names
    KSper
    calcium-activated potassium channel subunit alpha-3
    calcium-activated potassium channel, subfamily M subunit alpha-3
    pH-sensitive maxi potassium channel
    pore-forming subunit of the sperm-specific alkalization activated K(+) current
    potassium large conductance pH-sensitive channel, subfamily M, alpha member 3
    slowpoke homolog 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008432.3NP_032458.3  potassium channel subfamily U member 1

      See identical proteins and their annotated locations for NP_032458.3

      Status: VALIDATED

      Source sequence(s)
      AF039213, BQ175543, CJ042506
      Consensus CDS
      CCDS52530.1
      UniProtKB/Swiss-Prot
      D3Z5P2, G3X9P7, O54982
      Related
      ENSMUSP00000096457.4, ENSMUST00000098858.11
      Conserved Domains (3) summary
      pfam00520
      Location:133323
      Ion_trans; Ion transport protein
      pfam03493
      Location:469557
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:230316
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      26338656..26427971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312583.2XP_017168072.1  potassium channel subfamily U member 1 isoform X4

      Conserved Domains (2) summary
      pfam00520
      Location:12241
      Ion_trans; Ion transport protein
      pfam03493
      Location:387475
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    2. XM_006509024.2XP_006509087.1  potassium channel subfamily U member 1 isoform X1

      Conserved Domains (2) summary
      pfam00520
      Location:104333
      Ion_trans; Ion transport protein
      pfam03493
      Location:479567
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    3. XM_017312582.1XP_017168071.1  potassium channel subfamily U member 1 isoform X3

      Conserved Domains (2) summary
      pfam00520
      Location:104333
      Ion_trans; Ion transport protein
      pfam03493
      Location:479567
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    4. XM_017312581.1XP_017168070.1  potassium channel subfamily U member 1 isoform X2

      Conserved Domains (2) summary
      pfam00520
      Location:104333
      Ion_trans; Ion transport protein
      pfam03493
      Location:479567
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    RNA

    1. XR_003947237.1 RNA Sequence

    2. XR_003947236.1 RNA Sequence