U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Stap1 signal transducing adaptor family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 56792, updated on 3-Dec-2024

    Summary

    Official Symbol
    Stap1provided by MGI
    Official Full Name
    signal transducing adaptor family member 1provided by MGI
    Primary source
    MGI:MGI:1926193
    See related
    Ensembl:ENSMUSG00000029254 AllianceGenome:MGI:1926193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brdg1; STAP-1
    Summary
    Enables macrophage colony-stimulating factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including negative regulation of macrophage colony-stimulating factor signaling pathway; negative regulation of macrophage migration; and negative regulation of ruffle assembly. Acts upstream of or within response to bacterium. Predicted to be located in several cellular components, including centriolar satellite; mitochondrion; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human STAP1 (signal transducing adaptor family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stap1 in Genome Data Viewer
    Location:
    5 E1; 5 43.56 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (86219446..86251859)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (86071584..86106125)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene centromere protein C1 Neighboring gene STARR-seq mESC enhancer starr_13543 Neighboring gene STARR-positive B cell enhancer ABC_E1055 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:86498237-86498420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:86500459-86500642 Neighboring gene STARR-positive B cell enhancer ABC_E3586 Neighboring gene predicted gene 2287 Neighboring gene STARR-positive B cell enhancer ABC_E2747 Neighboring gene predicted gene, 24524 Neighboring gene ubiquitin-like modifier activating enzyme 6 Neighboring gene STARR-seq mESC enhancer starr_13544 Neighboring gene STARR-positive B cell enhancer ABC_E10326 Neighboring gene gonadotropin releasing hormone receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables macrophage colony-stimulating factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane receptor protein tyrosine kinase adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within myeloid cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of macrophage chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of macrophage colony-stimulating factor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of microglial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of microglial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of microglial cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    signal-transducing adaptor protein 1
    Names
    BCR downstream signaling 1
    stem cell adaptor protein STAP-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310639.1NP_001297568.1  signal-transducing adaptor protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK041474, AK162655, BF660908
      Consensus CDS
      CCDS80312.1
      UniProtKB/TrEMBL
      A0A0H2UKC0, B7ZP01
      Related
      ENSMUSP00000031171.9, ENSMUST00000031171.9
      Conserved Domains (2) summary
      cd10403
      Location:140233
      SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)
      cl17171
      Location:15101
      PH-like; Pleckstrin homology-like domain
    2. NM_001425532.1NP_001412461.1  signal-transducing adaptor protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC107634
      UniProtKB/TrEMBL
      B7ZP01
    3. NM_019992.4NP_064376.1  signal-transducing adaptor protein 1 isoform 1

      See identical proteins and their annotated locations for NP_064376.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK041474, AK162655, BF660908
      Consensus CDS
      CCDS19377.1
      UniProtKB/Swiss-Prot
      A6H6C6, Q3TRM1, Q6PES6, Q9JM90
      UniProtKB/TrEMBL
      B7ZP01
      Related
      ENSMUSP00000143251.2, ENSMUST00000198435.5
      Conserved Domains (3) summary
      cd10403
      Location:178271
      SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)
      pfam00169
      Location:26112
      PH; PH domain
      cl17171
      Location:15139
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      86219446..86251859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165360.1XP_036021253.1  signal-transducing adaptor protein 1 isoform X2

      Conserved Domains (1) summary
      cl17171
      Location:15121
      PH-like; Pleckstrin homology-like domain