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    Ifrd2 interferon-related developmental regulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 15983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ifrd2provided by MGI
    Official Full Name
    interferon-related developmental regulator 2provided by MGI
    Primary source
    MGI:MGI:1316708
    See related
    Ensembl:ENSMUSG00000010048 AllianceGenome:MGI:1316708
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SKMc15; 1810034A24Rik
    Summary
    Predicted to enable ribosome binding activity and translation repressor activity. Predicted to be involved in negative regulation of translation. Is expressed in several structures, including alimentary system; blood; embryo mesenchyme; extraembryonic component; and neural ectoderm. Orthologous to human IFRD2 (interferon related developmental regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 78.8), liver E14 (RPKM 68.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ifrd2 in Genome Data Viewer
    Location:
    9 F1; 9 58.24 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107464917..107470237)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107587718..107593038)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2304 Neighboring gene hyaluronoglucosaminidase 2 Neighboring gene STARR-seq mESC enhancer starr_25176 Neighboring gene hyaluronoglucosaminidase 1 Neighboring gene N(alpha)-acetyltransferase 80, NatH catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E300 Neighboring gene hyaluronoglucosaminidase 3 Neighboring gene leucine-rich single-pass membrane protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E11753 Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B Neighboring gene STARR-positive B cell enhancer ABC_E8314 Neighboring gene G protein subunit alpha i2 Neighboring gene predicted gene, 53518

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15). Vietor I, et al. Elife, 2023 Aug 21. PMID 37603466, Free PMC Article
    2. Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes. Buanne P, et al. Genomics, 1998 Jul 15. PMID 9722946
    3. Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX? Jadin L, et al. FASEB J, 2008 Dec. PMID 18772348
    4. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. Shuttleworth TL, et al. J Biol Chem, 2002 Jun 21. PMID 11929860
    5. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Lerman MI, et al. Cancer Res, 2000 Nov 1. PMID 11085536

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15).
      Title: The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    interferon-related developmental regulator 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025903.2 → NP_080179.1  interferon-related developmental regulator 2

      See identical proteins and their annotated locations for NP_080179.1

      Status: PROVISIONAL

      Source sequence(s)
      AK007687
      Consensus CDS
      CCDS23500.1
      UniProtKB/Swiss-Prot
      Q7TSB3, Q9CW96, Q9D8U0
      Related
      ENSMUSP00000010192.6, ENSMUST00000010192.11
      Conserved Domains (2) summary
      pfam04836
      Location:385 → 438
      IFRD_C; Interferon-related protein conserved region
      pfam05004
      Location:32 → 339
      IFRD; Interferon-related developmental regulator (IFRD)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107464917..107470237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8U0.1 GenPept UniProtKB/Swiss-Prot:Q9D8U0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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