Ddias DNA damage-induced apoptosis suppressor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddiasprovided by MGI
Official Full Name: DNA damage-induced apoptosis suppressorprovided by MGI
Primary source: MGI:MGI:1921291
See related: Ensembl:ENSMUSG00000030641 AllianceGenome:MGI:1921291
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: noxin; 4632434I11Rik
Summary: Acts upstream of or within several processes, including cellular response to hydroperoxide; cellular response to radiation; and negative regulation of fibroblast apoptotic process. Located in cytoplasm and nucleus. Orthologous to human DDIAS (DNA damage induced apoptosis suppressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 4.8), liver E14 (RPKM 2.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 51.64 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (92506734..92523455, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (92857525..92874917, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Noxin may be a component of the cell defense system: it is activated by various stress stimuli, helps cells to withdraw from cycling, and opposes apoptosis.
Title: noxin, a novel stress-induced gene involved in cell cycle and apoptosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to cytokine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to hydroperoxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibroblast apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA stability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA damage-induced apoptosis suppressor protein

Names: nitric oxide-inducible gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080995.2 → NP_001074464.1 DNA damage-induced apoptosis suppressor protein

See identical proteins and their annotated locations for NP_001074464.1

Status: VALIDATED

Source sequence(s)

AC158138

Consensus CDS

CCDS40022.1

UniProtKB/Swiss-Prot

A2T1E9, Q6NZG4

UniProtKB/TrEMBL

E9QLR9

Conserved Domains (1) summary

cl09930
Location:8 → 102

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
NM_001355126.1 → NP_001342055.1 DNA damage-induced apoptosis suppressor protein

Status: VALIDATED

Source sequence(s)

AC158138

Consensus CDS

CCDS40022.1

UniProtKB/Swiss-Prot

A2T1E9, Q6NZG4

UniProtKB/TrEMBL

E9QLR9

Related

ENSMUSP00000032877.10, ENSMUST00000032877.11

Conserved Domains (1) summary

cl09930
Location:8 → 102

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
NM_001368705.1 → NP_001355634.1 DNA damage-induced apoptosis suppressor protein

Status: VALIDATED

Source sequence(s)

AC158138

Consensus CDS

CCDS40022.1

UniProtKB/Swiss-Prot

A2T1E9, Q6NZG4

UniProtKB/TrEMBL

E9QLR9

Conserved Domains (1) summary

cl09930
Location:8 → 102

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

92506734..92523455 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_028729.1: Suppressed sequence

Description

NM_028729.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.