Eno2 enolase 2, gamma neuronal [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eno2provided by MGI
Official Full Name: enolase 2, gamma neuronalprovided by MGI
Primary source: MGI:MGI:95394
See related: Ensembl:ENSMUSG00000004267 AllianceGenome:MGI:95394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NSE; Eno-2; D6Ertd375e
Summary: Predicted to enable enzyme binding activity; identical protein binding activity; and phosphopyruvate hydratase activity. Predicted to be involved in canonical glycolysis and gluconeogenesis. Located in cytoplasm; perikaryon; and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ENO2 (enolase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 147.0), frontal lobe adult (RPKM 120.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F2; 6 59.17 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (124737018..124746489, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (124760053..124769673, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development.
Title: Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development.
miR153 promoted neural differentiation and protected neural cells by upregulating the neuron markers gammaenolase, neuronal nuclei, and the functional proteins SNAP23, SNAP25 and PRX5.
Title: miR‑153 promotes neural differentiation in the mouse hippocampal HT‑22 cell line and increases the expression of neuron‑specific enolase.
Study analyzed the regions that regulate the promoter strength and cellular specificity of the 1.8 kb rNSE promoter in the cerebellum in vivo. The rNSE promoter was divided into three regions (A, B, and C). Our results showed that region C was indispensable for the promoter activity in mouse cerebellum and served as an interneuron-predominant basal promoter.
Title: Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo.
Plaque-associated microglial cells express gamma-enolase and cathepsin X.
Title: Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X.
Treadmill exercise training decreased the expression of NSN in the striatum of chronic Parkinsonian mice, which can partially explain the beneficial neuroprotective role of exercise in patients with parkinson disease.
Title: Effect of endurance exercise training on the expression of GFAP, S100B, and NSE in the striatum of chronic/progressive mouse model of Parkinson's disease.
we induced differentiation of mouse stromal cells to neuron-like cells and observed the activation of tissue-specific promoter of neuron-specific enolase in transgenic mice with the human bcl-2 gene expressed only in neurons under the NSE promoter
Title: Induction of neuron-specific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI837106 (e-PCR)
- UniSTS:179460

Eno2 (e-PCR), detects polymorphism
- UniSTS:516632

RH127101 (e-PCR)
- UniSTS:167482

MARC_4643-4644:966894536:1 (e-PCR)
- UniSTS:269413

Eno2 (e-PCR), detects polymorphism
- UniSTS:142991

UniSTS:142992 (e-PCR)
- UniSTS:142992

Eno2 (e-PCR), detects polymorphism
- UniSTS:142992

BB431127 (e-PCR)
- UniSTS:208033

Eno2 (e-PCR), detects polymorphism
- UniSTS:265660

Eno2 (e-PCR), detects polymorphism
- UniSTS:506879

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphopyruvate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphopyruvate hydratase activity	IEA Inferred from Electronic Annotation more info
enables phosphopyruvate hydratase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
part_of phosphopyruvate hydratase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphopyruvate hydratase complex	IEA Inferred from Electronic Annotation more info
part_of phosphopyruvate hydratase complex	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-enolase

Names: 2-phospho-D-glycerate hydro-lyase; neural enolase; neuron-specific enolase

NP_001289571.1

EC 4.2.1.11

NP_001342149.1

EC 4.2.1.11

NP_001396615.1

EC 4.2.1.11

NP_001396616.1

EC 4.2.1.11

NP_001396617.1

EC 4.2.1.11

NP_001396618.1

EC 4.2.1.11

NP_001396619.1

EC 4.2.1.11

NP_038537.1

EC 4.2.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302642.2 → NP_001289571.1 gamma-enolase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two in-frame exons in the coding region compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1. Variants 2, 7, and 8 all encode the same isoform (2).

Source sequence(s)

AC164157

Consensus CDS

CCDS80609.1

UniProtKB/TrEMBL

D3Z6E4, Q922A0

Related

ENSMUSP00000108095.2, ENSMUST00000112476.8

Conserved Domains (1) summary

PLN00191
Location:2 → 313

PLN00191; enolase
NM_001355220.2 → NP_001342149.1 gamma-enolase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3-6 all encode the same isoform (1).

Source sequence(s)

AC164157

Consensus CDS

CCDS20527.1

UniProtKB/Swiss-Prot

P17183

UniProtKB/TrEMBL

Q3UJ20, Q545V3

Conserved Domains (1) summary

PLN00191
Location:2 → 432

PLN00191; enolase
NM_001409686.1 → NP_001396615.1 gamma-enolase isoform 1

Status: VALIDATED

Source sequence(s)

AC164157

UniProtKB/Swiss-Prot

P17183

UniProtKB/TrEMBL

Q3UJ20, Q545V3
NM_001409687.1 → NP_001396616.1 gamma-enolase isoform 1

Status: VALIDATED

Source sequence(s)

AC164157

UniProtKB/Swiss-Prot

P17183

UniProtKB/TrEMBL

Q3UJ20, Q545V3
NM_001409688.1 → NP_001396617.1 gamma-enolase isoform 1

Status: VALIDATED

Source sequence(s)

AC164157

UniProtKB/Swiss-Prot

P17183

UniProtKB/TrEMBL

Q3UJ20, Q545V3
NM_001409689.1 → NP_001396618.1 gamma-enolase isoform 2

Status: VALIDATED

Source sequence(s)

AC164157

UniProtKB/TrEMBL

D3Z6E4, Q922A0
NM_001409690.1 → NP_001396619.1 gamma-enolase isoform 2

Status: VALIDATED

Source sequence(s)

AC164157

UniProtKB/TrEMBL

D3Z6E4, Q922A0
NM_013509.4 → NP_038537.1 gamma-enolase isoform 1

See identical proteins and their annotated locations for NP_038537.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3-6 all encode the same isoform (1).

Source sequence(s)

AC164157

Consensus CDS

CCDS20527.1

UniProtKB/Swiss-Prot

P17183

UniProtKB/TrEMBL

Q3UJ20, Q545V3

Related

ENSMUSP00000004378.9, ENSMUST00000004378.15

Conserved Domains (1) summary

PLN00191
Location:2 → 432

PLN00191; enolase