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    Egr4 early growth response 4 [ Mus musculus (house mouse) ]

    Gene ID: 13656, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Egr4provided by MGI
    Official Full Name
    early growth response 4provided by MGI
    Primary source
    MGI:MGI:99252
    See related
    Ensembl:ENSMUSG00000071341 AllianceGenome:MGI:99252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NGFIC; NGF1-C; NGFI-C; pAT133
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and tooth. Orthologous to human EGR4 (early growth response 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 10.9), cortex adult (RPKM 9.9) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Egr4 in Genome Data Viewer
    Location:
    6 C3; 6 37.48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85488103..85490571, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85511121..85513589, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene protease-associated domain containing 1 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene F-box protein 41 Neighboring gene ALMS1, centrosome and basal body associated Neighboring gene STARR-seq mESC enhancer starr_16505 Neighboring gene STARR-seq mESC enhancer starr_16506 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 7 Neighboring gene ALMS1, centrosome and basal body associated, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EGR4 is critical for cell-fate determination and phenotypic maintenance of geniculate ganglion neurons underlying sweet and umami taste. Dutta Banik D, et al. Proc Natl Acad Sci U S A, 2023 May 30. PMID 37216536, Free PMC Article
    2. Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice. Tourtellotte WG, et al. Development, 1999 Nov. PMID 10529423
    3. EGR4 displays both a cell- and intracellular-specific localization pattern in the developing murine testis. Hogarth CA, et al. Dev Dyn, 2010 Nov. PMID 20925118, Free PMC Article
    4. Cloning and characterization of the bovine EGR4 gene and evaluation as candidate gene for bovine spinal dysmyelination. Nissen PH, et al. Anim Genet, 2003 Apr. PMID 12648095
    5. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. Holst C, et al. Hum Mol Genet, 1993 Apr. PMID 8504297

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suppression of Ca(2+) signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo.
      Title: Suppression of Ca(2+) signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo.
    2. Egr4 expression is triggered by trophic factor neurturin to upregulate K-Cl cotransporter KCC2 in immature neurons.
      Title: Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons.
    3. Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons.
      Title: Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription.
    4. Data suggest that Egr4 may regulate spermatogenesis at multiple steps, with roles in the dividing Sertoli cells, peritubular myoid cells, and the meiotic and elongating haploid germ cell populations.
      Title: EGR4 displays both a cell- and intracellular-specific localization pattern in the developing murine testis.
    5. An important role for Egr4 is indicated in the developmental upregulation of potassium-chloride cotransporter (KCC2) gene expression.
      Title: Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    early growth response protein 4
    Names
    EGR-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020596.3 → NP_065621.1  early growth response protein 4

      See identical proteins and their annotated locations for NP_065621.1

      Status: VALIDATED

      Source sequence(s)
      AK141637, BX528200
      Consensus CDS
      CCDS20297.1
      UniProtKB/Swiss-Prot
      Q9WUF2
      UniProtKB/TrEMBL
      Q3URA9
      Related
      ENSMUSP00000093433.4, ENSMUST00000095759.5
      Conserved Domains (4) summary
      COG5048
      Location:400 → 458
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:374 → 396
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 396
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:416 → 441
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      85488103..85490571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUF2.1 GenPept UniProtKB/Swiss-Prot:Q9WUF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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