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    Elf2 E74-like factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 69257, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Elf2provided by MGI
    Official Full Name
    E74-like factor 2provided by MGI
    Primary source
    MGI:MGI:1916507
    See related
    Ensembl:ENSMUSG00000037174 AllianceGenome:MGI:1916507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EU32; NERF; NERF-2; NERF-1A; NERF-1B; 2610036A20Rik; A230104O07Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation and regulation of DNA-templated transcription. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; reproductive system; sensory organ; and urinary system. Orthologous to human ELF2 (E74 like ETS transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.4), thymus adult (RPKM 9.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Elf2 in Genome Data Viewer
    Location:
    3 C; 3 22.19 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51160141..51248101, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51252720..51340683, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07602 Neighboring gene predicted gene, 40044 Neighboring gene nocturnin Neighboring gene RIKEN cDNA 4930577N17 gene Neighboring gene STARR-positive B cell enhancer ABC_E148 Neighboring gene STARR-positive B cell enhancer ABC_E10178 Neighboring gene STARR-positive B cell enhancer ABC_E6050 Neighboring gene nuclear encoded tRNA proline 7 (anticodon TGG) Neighboring gene nuclear encoded tRNA proline 5 (anticodon AGG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo. Guan FH, et al. J Hematol Oncol, 2017 Mar 28. PMID 28351373, Free PMC Article
    2. Ets proteins in biological control and cancer. Hsu T, et al. J Cell Biochem, 2004 Apr 1. PMID 15034925, Free PMC Article
    3. An Elf2-like transcription factor acts as repressor of the mouse ecto-5'-nucleotidase gene expression in hepatic myofibroblasts. Fausther M, et al. Purinergic Signal, 2017 Dec. PMID 28667437, Free PMC Article
    4. Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter. Iljin K, et al. FASEB J, 1999 Feb. PMID 9973326
    5. eIF2α phosphorylation controls thermal nociception. Khoutorsky A, et al. Proc Natl Acad Sci U S A, 2016 Oct 18. PMID 27698114, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102660

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ETS-related transcription factor Elf-2
    Names
    ets domain transcription factor
    ets family transcription factor ELF2A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291059.1 → NP_001277988.1  ETS-related transcription factor Elf-2 isoform 2

      See identical proteins and their annotated locations for NP_001277988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC118601, AC161183, AK146819
      Consensus CDS
      CCDS71242.1
      UniProtKB/TrEMBL
      Q3TVH6, Q58E60
      Related
      ENSMUSP00000061076.7, ENSMUST00000062009.14
      Conserved Domains (2) summary
      pfam00178
      Location:197 → 277
      Ets; Ets-domain
      pfam12310
      Location:3 → 108
      Elf-1_N; Transcription factor protein N terminal

    2. NM_001291062.1 → NP_001277991.1  ETS-related transcription factor Elf-2 isoform 3

      See identical proteins and their annotated locations for NP_001277991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' structure and an alternate splice site in the coding region compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC118601, AC161183, AF256218
      Consensus CDS
      CCDS71240.1
      UniProtKB/TrEMBL
      A0A0B4J1G5
      Related
      ENSMUSP00000103686.2, ENSMUST00000108051.8
      Conserved Domains (2) summary
      pfam00178
      Location:138 → 217
      Ets; Ets-domain
      pfam12310
      Location:20 → 48
      Elf-1_N; Transcription factor protein N terminal

    3. NM_001291063.1 → NP_001277992.1  ETS-related transcription factor Elf-2 isoform 4

      See identical proteins and their annotated locations for NP_001277992.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' structure compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC118601, AC161183, AF256219
      Consensus CDS
      CCDS71241.1
      UniProtKB/TrEMBL
      A0A0B4J1G5
      Related
      ENSMUSP00000103688.3, ENSMUST00000108053.9
      Conserved Domains (2) summary
      pfam00178
      Location:150 → 229
      Ets; Ets-domain
      pfam12310
      Location:20 → 48
      Elf-1_N; Transcription factor protein N terminal

    4. NM_001356358.1 → NP_001343287.1  ETS-related transcription factor Elf-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC118601, AC161183
      UniProtKB/TrEMBL
      A0A0B4J1G5
      Conserved Domains (2) summary
      pfam00178
      Location:118 → 198
      Ets; Ets-domain
      pfam12310
      Location:2 → 29
      Elf-1_N; Transcription factor protein N terminal

    5. NM_023502.2 → NP_075991.1  ETS-related transcription factor Elf-2 isoform 1

      See identical proteins and their annotated locations for NP_075991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC118601, AC161183, AF256217
      Consensus CDS
      CCDS17337.1
      UniProtKB/Swiss-Prot
      Q6NST2, Q8BTX8, Q9JHC7, Q9JHC8, Q9JHC9, Q9JHD0
      UniProtKB/TrEMBL
      Q58E60
      Related
      ENSMUSP00000141197.2, ENSMUST00000194641.6
      Conserved Domains (2) summary
      pfam00178
      Location:209 → 289
      Ets; Ets-domain
      pfam12310
      Location:3 → 108
      Elf-1_N; Transcription factor protein N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      51160141..51248101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319714.3 → XP_017175203.1  ETS-related transcription factor Elf-2 isoform X5

      UniProtKB/TrEMBL
      Q3UZ20
      Conserved Domains (1) summary
      pfam00178
      Location:105 → 185
      Ets; Ets-domain

    2. XM_036163288.1 → XP_036019181.1  ETS-related transcription factor Elf-2 isoform X2

      UniProtKB/TrEMBL
      Q3TVH6, Q58E60
      Conserved Domains (2) summary
      pfam00178
      Location:197 → 277
      Ets; Ets-domain
      pfam12310
      Location:3 → 108
      Elf-1_N; Transcription factor protein N terminal

    3. XM_030252804.1 → XP_030108664.1  ETS-related transcription factor Elf-2 isoform X6

      UniProtKB/TrEMBL
      Q3UZ20
      Conserved Domains (1) summary
      pfam00178
      Location:94 → 173
      Ets; Ets-domain

    4. XM_036163287.1 → XP_036019180.1  ETS-related transcription factor Elf-2 isoform X1

      UniProtKB/Swiss-Prot
      Q6NST2, Q8BTX8, Q9JHC7, Q9JHC8, Q9JHC9, Q9JHD0
      UniProtKB/TrEMBL
      Q58E60
      Related
      ENSMUSP00000126871.2, ENSMUST00000163748.8
      Conserved Domains (2) summary
      pfam00178
      Location:209 → 289
      Ets; Ets-domain
      pfam12310
      Location:3 → 108
      Elf-1_N; Transcription factor protein N terminal

    5. XM_030252807.1 → XP_030108667.1  ETS-related transcription factor Elf-2 isoform X7

      UniProtKB/TrEMBL
      Q3UZ20
      Conserved Domains (1) summary
      pfam00178
      Location:74 → 154
      Ets; Ets-domain

    6. XM_006502031.4 → XP_006502094.1  ETS-related transcription factor Elf-2 isoform X3

      See identical proteins and their annotated locations for XP_006502094.1

      UniProtKB/TrEMBL
      A0A0B4J1G5
      Conserved Domains (2) summary
      pfam00178
      Location:130 → 210
      Ets; Ets-domain
      pfam12310
      Location:2 → 29
      Elf-1_N; Transcription factor protein N terminal

    7. XM_036163295.1 → XP_036019188.1  ETS-related transcription factor Elf-2 isoform X7

      UniProtKB/TrEMBL
      Q3UZ20
      Conserved Domains (1) summary
      pfam00178
      Location:74 → 154
      Ets; Ets-domain

    8. XM_036163291.1 → XP_036019184.1  ETS-related transcription factor Elf-2 isoform X4

      UniProtKB/TrEMBL
      A0A0B4J1G5
      Conserved Domains (2) summary
      pfam00178
      Location:118 → 198
      Ets; Ets-domain
      pfam12310
      Location:2 → 29
      Elf-1_N; Transcription factor protein N terminal

    9. XM_036163289.1 → XP_036019182.1  ETS-related transcription factor Elf-2 isoform X3

      UniProtKB/TrEMBL
      A0A0B4J1G5
      Conserved Domains (2) summary
      pfam00178
      Location:130 → 210
      Ets; Ets-domain
      pfam12310
      Location:2 → 29
      Elf-1_N; Transcription factor protein N terminal

    10. XM_036163290.1 → XP_036019183.1  ETS-related transcription factor Elf-2 isoform X3

      UniProtKB/TrEMBL
      A0A0B4J1G5
      Conserved Domains (2) summary
      pfam00178
      Location:130 → 210
      Ets; Ets-domain
      pfam12310
      Location:2 → 29
      Elf-1_N; Transcription factor protein N terminal

    11. XM_036163292.1 → XP_036019185.1  ETS-related transcription factor Elf-2 isoform X5

      UniProtKB/TrEMBL
      Q3UZ20
      Conserved Domains (1) summary
      pfam00178
      Location:105 → 185
      Ets; Ets-domain

    12. XM_030252805.1 → XP_030108665.1  ETS-related transcription factor Elf-2 isoform X6

      UniProtKB/TrEMBL
      Q3UZ20
      Conserved Domains (1) summary
      pfam00178
      Location:94 → 173
      Ets; Ets-domain

    13. XM_036163293.1 → XP_036019186.1  ETS-related transcription factor Elf-2 isoform X5

      UniProtKB/TrEMBL
      Q3UZ20
      Conserved Domains (1) summary
      pfam00178
      Location:105 → 185
      Ets; Ets-domain

    14. XM_030252806.1 → XP_030108666.1  ETS-related transcription factor Elf-2 isoform X7

      UniProtKB/TrEMBL
      Q3UZ20
      Conserved Domains (1) summary
      pfam00178
      Location:74 → 154
      Ets; Ets-domain

    15. XM_006502034.5 → XP_006502097.1  ETS-related transcription factor Elf-2 isoform X7

      See identical proteins and their annotated locations for XP_006502097.1

      UniProtKB/TrEMBL
      Q3UZ20
      Conserved Domains (1) summary
      pfam00178
      Location:74 → 154
      Ets; Ets-domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHC9.1 GenPept UniProtKB/Swiss-Prot:Q9JHC9

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