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    Stkld1 serine/threonine kinase-like domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 279029, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Stkld1provided by MGI
    Official Full Name
    serine/threonine kinase-like domain containing 1provided by MGI
    Primary source
    MGI:MGI:2685557
    See related
    Ensembl:ENSMUSG00000049897 AllianceGenome:MGI:2685557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm711; Sgk071
    Summary
    Predicted to enable protein serine/threonine kinase activity. Orthologous to human STKLD1 (serine/threonine kinase like domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 36.3), duodenum adult (RPKM 31.6) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stkld1 in Genome Data Viewer
    Location:
    2 A3; 2 19.12 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26823533..26843508)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26933521..26953496)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 57689 Neighboring gene ribosomal protein L7A Neighboring gene surfeit gene 1 Neighboring gene surfeit gene 2 Neighboring gene surfeit gene 4 Neighboring gene STARR-positive B cell enhancer ABC_E2605 Neighboring gene REX4, 3'-5' exonuclease Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26819876-26820059 Neighboring gene predicted gene, 36649 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC58758

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine kinase-like domain-containing protein STKLD1
    Names
    likely ortholog of H. sapiens chromosome 9 open reading frame 96 (C9orf96)
    probable inactive protein kinase-like protein SgK071 homolog
    probable protein kinase-like protein SgK071 homolog
    serine/threonine kinase-like domain-containing protein 1
    sugen kinase 071

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379463.1 → NP_001366392.1  serine/threonine kinase-like domain-containing protein STKLD1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL773563
      Conserved Domains (1) summary
      smart00220
      Location:4 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_001379464.1 → NP_001366393.1  serine/threonine kinase-like domain-containing protein STKLD1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Conserved Domains (1) summary
      smart00220
      Location:4 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    3. NM_198628.3 → NP_941030.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform 2

      See identical proteins and their annotated locations for NP_941030.2

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Consensus CDS
      CCDS15818.1
      UniProtKB/Swiss-Prot
      A2ALB0, Q80YS9
      Related
      ENSMUSP00000062967.9, ENSMUST00000055406.9
      Conserved Domains (1) summary
      smart00220
      Location:5 → 266
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26823533..26843508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498110.4 → XP_006498173.1  serine/threonine kinase-like domain-containing protein STKLD1 isoform X1

      See identical proteins and their annotated locations for XP_006498173.1

      Conserved Domains (1) summary
      smart00220
      Location:5 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. XM_006498109.5 → XP_006498172.1  serine/threonine kinase-like domain-containing protein STKLD1 isoform X3

      Conserved Domains (1) summary
      smart00220
      Location:4 → 286
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    3. XM_006498107.4 → XP_006498170.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform X1

      See identical proteins and their annotated locations for XP_006498170.2

      Conserved Domains (1) summary
      smart00220
      Location:5 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    4. XM_006498112.5 → XP_006498175.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform X5

      Conserved Domains (1) summary
      smart00220
      Location:5 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    5. XM_006498108.5 → XP_006498171.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform X2

      Conserved Domains (1) summary
      smart00220
      Location:5 → 266
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    6. XM_006498111.5 → XP_006498174.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform X4

      Conserved Domains (1) summary
      smart00220
      Location:5 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    7. XM_006498113.5 → XP_006498176.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform X6

      See identical proteins and their annotated locations for XP_006498176.2

      UniProtKB/Swiss-Prot
      A2ALB0, Q80YS9
      Conserved Domains (1) summary
      smart00220
      Location:5 → 266
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    8. XM_006498114.1 → XP_006498177.1  serine/threonine kinase-like domain-containing protein STKLD1 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:38 → 134
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YS9.3 GenPept UniProtKB/Swiss-Prot:Q80YS9

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