Inava innate immunity activator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inavaprovided by MGI
Official Full Name: innate immunity activatorprovided by MGI
Primary source: MGI:MGI:1921579
See related: Ensembl:ENSMUSG00000041605 AllianceGenome:MGI:1921579
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D1Mgi54; 1700034M08Rik; 4933426C09Rik; 5730559C18Rik
Summary: Involved in adherens junction maintenance; intestinal epithelial structure maintenance; and positive regulation of protein ubiquitination. Predicted to be located in cytoplasm and nuclear body. Is expressed in gut; metanephros; olfactory epithelium; respiratory system; and submandibular gland primordium. Human ortholog(s) of this gene implicated in inflammatory bowel disease 29. Orthologous to human INAVA (innate immunity activator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 37.5), stomach adult (RPKM 18.3) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 59.61 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (136141259..136162045, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (136213522..136234293, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in adherens junction maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in adherens junction maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in adherens junction maintenance	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in intestinal epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in pattern recognition receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in response to muramyl dipeptide	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to peptidoglycan	ISO Inferred from Sequence Orthology more info
involved_in response to peptidoglycan	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: innate immunity activator protein

Names: uncharacterized protein C1orf106 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405152.1 → NP_001392081.1 innate immunity activator protein isoform 2

Status: VALIDATED

Source sequence(s)

AC124550
NM_001405153.1 → NP_001392082.1 innate immunity activator protein isoform 3

Status: VALIDATED

Source sequence(s)

AC124550
NM_001405154.1 → NP_001392083.1 innate immunity activator protein isoform 4

Status: VALIDATED

Source sequence(s)

AC124550
NM_028872.4 → NP_083148.4 innate immunity activator protein isoform 1

Status: VALIDATED

Source sequence(s)

AC124550

Consensus CDS

CCDS15325.2

UniProtKB/Swiss-Prot

Q7TN12, Q7TN27, Q8BGK3

Related

ENSMUSP00000113785.3, ENSMUST00000120339.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

136141259..136162045 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153122.1 → XP_036009015.1 innate immunity activator protein isoform X2

UniProtKB/TrEMBL

G3X9Z8

Conserved Domains (1) summary

pfam11819
Location:2 → 130

DUF3338; Domain of unknown function (DUF3338)
XM_036153121.1 → XP_036009014.1 innate immunity activator protein isoform X2

UniProtKB/TrEMBL

G3X9Z8

Conserved Domains (1) summary

pfam11819
Location:2 → 130

DUF3338; Domain of unknown function (DUF3338)