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    B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [ Homo sapiens (human) ]

    Gene ID: 374907, updated on 27-Nov-2024

    Summary

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    Official Symbol
    B3GNT8provided by HGNC
    Official Full Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8provided by HGNC
    Primary source
    HGNC:HGNC:24139
    See related
    Ensembl:ENSG00000177191 MIM:615357; AllianceGenome:HGNC:24139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B3GALT7; BGALT15; beta3Gn-T8
    Summary
    Enables protein N-acetylglucosaminyltransferase activity. Involved in poly-N-acetyllactosamine biosynthetic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in small intestine (RPKM 4.8), duodenum (RPKM 4.7) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See B3GNT8 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41425359..41428730, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44246583..44249963, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41931264..41934635, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41892254-41892432 Neighboring gene exosome component 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41903234-41903906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41903907-41904578 Neighboring gene branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41912476-41913430 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:41913431-41914386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10667 Neighboring gene VISTA enhancer hs1948 Neighboring gene distal membrane arm assembly component 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14682 Neighboring gene glutamate rich 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transcription factor c-jun regulates β3Gn-T8 expression in gastric cancer cell line SGC-7901. Jiang Z, et al. Oncol Rep, 2016 Sep. PMID 27459970
    2. Knockdown of β3GnT8 reverses 5-fluorouracil resistance in human colorectal cancer cells via inhibition the biosynthesis of polylactosamine-type N-glycans. Shen L, et al. Int J Oncol, 2014 Dec. PMID 25269761
    3. High expression of β3GnT8 is associated with the metastatic potential of human glioma. Liu J, et al. Int J Mol Med, 2014 Jun. PMID 24715095, Free PMC Article
    4. β3GnT8 regulates laryngeal carcinoma cell proliferation via targeting MMPs/TIMPs and TGF-β1. Hua D, et al. Asian Pac J Cancer Prev, 2012. PMID 22901175
    5. Down-regulation of β-1,3-N-acetylglucosaminyltransferase-8 by siRNA inhibits the growth of human gastric cancer. Liu Z, et al. Mol Med Rep, 2011 May-Jun. PMID 21468598

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nglycosylation and receptor tyrosine kinase signaling affect claudin3 levels in colorectal cancer cells.
      Title: N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.
    2. These results revealed that b3GnT8 may play a key role in the development of oxaliplatin resistance in colon cancer cells possibly through the alteration of the glycosylation of integrin beta1. These findings may be valuable for overcoming drug resistance in colon cancer
      Title: β3GnT8 regulates oxaliplatin resistance by altering integrin β1 glycosylation in colon cancer cells.
    3. Cjun plays a significant role in regulating the expression of beta3GnT8 in the SGC7901 cell line.
      Title: Transcription factor c-jun regulates β3Gn-T8 expression in gastric cancer cell line SGC-7901.
    4. Study shows that beta3GnT8 is involved in the regulation of CD147 N-glycosylation and further influences MMP-2 expression in tumor cells suggesting that it may play an important role in the CD147 signaling as an upstream modulator of MMP-2 in tumor cells.
      Title: β3GnT8 plays an important role in CD147 signal transduction as an upstream modulator of MMP production in tumor cells.
    5. In conclusion, the alteration of b3GnT8 in colorectal cancer cells correlates with tumor sensitivity to the chemotherapeutic drug and has significant implication for the development of new treatment strategies.
      Title: Knockdown of β3GnT8 reverses 5-fluorouracil resistance in human colorectal cancer cells via inhibition the biosynthesis of polylactosamine-type N-glycans.
    6. The results demonstrated a critical role of beta3GnT8 in the metastatic potential of glioma cells, indicating that manipulating beta3GnT8 expression may have therapeutic potential for the treatment of malignant glioma.
      Title: High expression of β3GnT8 is associated with the metastatic potential of human glioma.
    7. we suggest that beta3GnT8 plays a key role in the metastasis of colorectal cancer cells by altering the beta1,6-branched polylactosamine sugars of CD147.
      Title: β3GnT8 regulates the metastatic potential of colorectal carcinoma cells by altering the glycosylation of CD147.
    8. High beta3Gn-T8 expression is associated with laryngeal carcinoma.
      Title: β3GnT8 regulates laryngeal carcinoma cell proliferation via targeting MMPs/TIMPs and TGF-β1.
    9. The down-regulation of beta3Gn-T8 caused significant inhibition of tumor cell growth in vitro.
      Title: Down-regulation of β-1,3-N-acetylglucosaminyltransferase-8 by siRNA inhibits the growth of human gastric cancer.
    10. These results reveal a new mechanism by which beta3Gn-T8 can regulate MMP-2 and TIMP-2.
      Title: Regulation of MMP-2 expression and activity by β-1,3-N-acetylglucosaminyltransferase-8 in AGS gastric cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in O-glycan processing TAS
    Traceable Author Statement
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
    Names
    BGnT-8
    UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7
    beta galactosyltransferase BGALT15
    beta-1,3-Gn-T8
    beta-1,3-N-acetylglucosaminyltransferase 8
    beta1,3-N-acetylglucosaminyltransferase 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385648.2 → NP_001372577.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC011462
      Consensus CDS
      CCDS12582.1
      UniProtKB/Swiss-Prot
      Q7Z7M8
      Related
      ENSP00000510371.1, ENST00000691102.1
      Conserved Domains (1) summary
      cl21608
      Location:162 → 349
      Galactosyl_T; Galactosyltransferase

    2. NM_198540.2 → NP_940942.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

      See identical proteins and their annotated locations for NP_940942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AY277592
      Consensus CDS
      CCDS12582.1
      UniProtKB/Swiss-Prot
      Q7Z7M8
      Related
      ENSP00000312700.1, ENST00000321702.2
      Conserved Domains (1) summary
      cl21608
      Location:162 → 349
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      41425359..41428730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44246583..44249963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7M8.1 GenPept UniProtKB/Swiss-Prot:Q7Z7M8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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