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    LINC00665 long intergenic non-protein coding RNA 665 [ Homo sapiens (human) ]

    Gene ID: 100506930, updated on 22-Oct-2024

    Summary

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    Official Symbol
    LINC00665provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 665provided by HGNC
    Primary source
    HGNC:HGNC:44323
    See related
    Ensembl:ENSG00000232677 AllianceGenome:HGNC:44323
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIP2A-BP
    Expression
    Ubiquitous expression in thyroid (RPKM 5.2), kidney (RPKM 3.8) and 24 other tissues See more
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    Genomic context

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    See LINC00665 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36313061..36331718, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38987945..39006613, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36803963..36822620, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36759575-36760152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36762631-36763222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36770206-36770810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36775291-36775913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36786728-36787343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36787344-36787958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36790483-36791084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36791085-36791685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36793635-36794244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36796811-36797424 Neighboring gene uncharacterized LOC100134317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36818663-36819164 Neighboring gene MPRA-validated peak3460 silencer Neighboring gene ZFP14 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10548 Neighboring gene ZFP82 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14522

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Micropeptide CIP2A-BP encoded by LINC00665 inhibits triple-negative breast cancer progression. Guo B, et al. EMBO J, 2020 Jan 2. PMID 31755573, Free PMC Article
    2. LINC00665 activates Wnt/β-catenin signaling pathway to facilitate tumor progression of colorectal cancer via upregulating CTNNB1. Han T, et al. Exp Mol Pathol, 2021 Jun. PMID 33865827
    3. LINC00665 promotes HeLa cell proliferation, migration, invasion and epithelial-mesenchymal transition by activating the WNT-CTNNB1/β‑catenin signaling pathway. Xia L, et al. Sheng Li Xue Bao, 2021 Apr 25. PMID 33903885
    4. Downregulation of LINC00665 confers decreased cell proliferation and invasion via the miR-138-5p/E2F3 signaling pathway in NSCLC. Wang H, et al. Biomed Pharmacother, 2020 Jul. PMID 32403047
    5. Long non-coding RNA LINC00665 promotes metastasis of breast cancer cells by triggering EMT. Zhou JL, et al. Eur Rev Med Pharmacol Sci, 2020 Mar. PMID 32271427

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer.
      Title: STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer.
    2. LINC00665 activating Wnt3a/beta-catenin signaling by bond with YBX1 promotes gastric cancer proliferation and metastasis.
      Title: LINC00665 activating Wnt3a/β-catenin signaling by bond with YBX1 promotes gastric cancer proliferation and metastasis.
    3. Overexpression of lncRNA LINC00665 inhibits the proliferation and chondroblast differentiation of bone marrow mesenchymal stem cells by targeting miR-214-3p.
      Title: Overexpression of lncRNA LINC00665 inhibits the proliferation and chondroblast differentiation of bone marrow mesenchymal stem cells by targeting miR-214-3p.
    4. Prognostic and clinicopathological values of LINC00665 in cancers: a systematic review and China population-based meta-analysis.
      Title: Prognostic and clinicopathological values of LINC00665 in cancers: a systematic review and China population-based meta-analysis.
    5. A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction.
      Title: A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction.
    6. A Feedback Loop of LINC00665 and the Wnt Signaling Pathway Expedites Osteosarcoma Cell Proliferation, Invasion, and Epithelial-Mesenchymal Transition.
      Title: A Feedback Loop of LINC00665 and the Wnt Signaling Pathway Expedites Osteosarcoma Cell Proliferation, Invasion, and Epithelial-Mesenchymal Transition.
    7. Hepatitis B Virus-Encoded HBsAg Contributes to Hepatocarcinogenesis by Inducing the Oncogenic Long Noncoding RNA LINC00665 through the NF-kappaB Pathway.
      Title: Hepatitis B Virus-Encoded HBsAg Contributes to Hepatocarcinogenesis by Inducing the Oncogenic Long Noncoding RNA LINC00665 through the NF-κB Pathway.
    8. LINC00665 affects the malignant biological behavior of ovarian cancer via the miR-148b-3p/KLF5.
      Title: LINC00665 affects the malignant biological behavior of ovarian cancer via the miR-148b-3p/KLF5.
    9. LncRNA LINC00665 Promotes Ovarian Cancer Cell Proliferation and Inhibits Apoptosis via Targeting miR-181a-5p/FHDC.
      Title: LncRNA LINC00665 Promotes Ovarian Cancer Cell Proliferation and Inhibits Apoptosis via Targeting miR-181a-5p/FHDC.
    10. MicroRNA-122-3p plays as the target of long non-coding RNA LINC00665 in repressing the progress of arthritis.
      Title: MicroRNA-122-3p plays as the target of long non-coding RNA LINC00665 in repressing the progress of arthritis.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • CIP2A binding peptide

    Clone Names

    • FLJ33508, AC092296.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038278.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC092296, BC041949
      Related
      ENST00000590622.5

    2. NR_038279.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon and includes two alternate 3' exons, compared to variant 1.
      Source sequence(s)
      AC092296, AI282277, BC041949, BU071001
      Related
      ENST00000449434.9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36313061..36331718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38987945..39006613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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