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    ZRSR2 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 [ Homo sapiens (human) ]

    Gene ID: 8233, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZRSR2provided by HGNC
    Official Full Name
    zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2provided by HGNC
    Primary source
    HGNC:HGNC:23019
    See related
    Ensembl:ENSG00000169249 MIM:300028; AllianceGenome:HGNC:23019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    URP; OFD21; ZC3H22; U2AF1L2; U2AF1RS2; U2AF1-RS2
    Summary
    This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 3.8), spleen (RPKM 3.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZRSR2 in Genome Data Viewer
    Location:
    Xp22.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (15790484..15823260)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (15373416..15406182)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (15808607..15841383)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CA5BP1-CA5B readthrough Neighboring gene small nucleolar RNA SNORA7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20673 Neighboring gene NANOG hESC enhancer GRCh37_chrX:15765293-15766154 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:15770987-15771772 Neighboring gene carbonic anhydrase 5B Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:15787311-15788154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:15809593-15810094 Neighboring gene inactivation escape 2 Neighboring gene adaptor related protein complex 1 subunit sigma 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20674 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:15872970-15873574 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:15926789-15927701 Neighboring gene RNA, U5F small nuclear 7, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC142014, MGC142040

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pre-mRNA 3'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pre-mRNA 3'-splice site binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IC
    Inferred by Curator
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spliceosomal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2AF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
    Names
    U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 2
    U2(RNU2) small nuclear RNA auxiliary factor 1-like 2
    U2AF35-related protein
    renal carcinoma antigen NY-REN-20
    zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012746.1 RefSeqGene

      Range
      5001..37810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_618

    mRNA and Protein(s)

    1. NM_005089.4NP_005080.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

      See identical proteins and their annotated locations for NP_005080.1

      Status: REVIEWED

      Source sequence(s)
      BC113480
      Consensus CDS
      CCDS14172.1
      UniProtKB/Swiss-Prot
      Q14D69, Q15696
      UniProtKB/TrEMBL
      Q86VN0
      Related
      ENSP00000303015.7, ENST00000307771.8
      Conserved Domains (2) summary
      cd12540
      Location:199303
      RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
      pfam00642
      Location:167191
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      15790484..15823260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545589.4XP_011543891.3  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X1

      Related
      ENSP00000510773.1, ENST00000684799.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      15373416..15406182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327930.1XP_054183905.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X1