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    CCNJL cyclin J like [ Homo sapiens (human) ]

    Gene ID: 79616, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CCNJLprovided by HGNC
    Official Full Name
    cyclin J likeprovided by HGNC
    Primary source
    HGNC:HGNC:25876
    See related
    Ensembl:ENSG00000135083 AllianceGenome:HGNC:25876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 4.2), lung (RPKM 2.2) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCNJL in Genome Data Viewer
    Location:
    5q33.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (160249083..160339570, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (160777639..160868099, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159676090..159766577, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159487609-159488120 Neighboring gene MPRA-validated peak5557 silencer Neighboring gene PWWP domain containing 2A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159507098-159508004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159508005-159508910 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:159513521-159513688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23555 Neighboring gene MPRA-validated peak5558 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159546009-159546508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23557 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159588248-159588903 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159589561-159590215 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159591897-159592496 Neighboring gene Sharpr-MPRA regulatory region 721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:159593698-159594298 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159602660-159603248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16579 Neighboring gene MPRA-validated peak5559 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16580 Neighboring gene FABP6 antisense RNA 1 Neighboring gene fatty acid binding protein 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16581 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159664401-159665356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23558 Neighboring gene uncharacterized LOC105377691 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159705762-159706289 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159713163-159713896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159712429-159713162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159715411-159716388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16583 Neighboring gene SNRPE pseudogene 1 Neighboring gene C1q and TNF related 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159825203-159825702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159826022-159826707 Neighboring gene family with sequence similarity 200 member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Comprehensive Analysis of Cyclin Family Gene Expression in Colon Cancer. Li J, et al. Front Oncol, 2021. PMID 33996604, Free PMC Article
    2. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
    3. Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Golkowski M, et al. Mol Cell, 2023 Mar 2. PMID 36736316, Free PMC Article
    4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
    5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14166

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-J-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308173.3 → NP_001295102.1  cyclin-J-like protein isoform b

      See identical proteins and their annotated locations for NP_001295102.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AC112191, AK302823, BC013353, BF111450
      Consensus CDS
      CCDS78082.1
      UniProtKB/TrEMBL
      B4DZA8, B5MDN2
      Related
      ENSP00000257536.7, ENST00000257536.13
      Conserved Domains (2) summary
      pfam02984
      Location:145 → 247
      Cyclin_C; Cyclin, C-terminal domain
      cl00050
      Location:14 → 107
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    2. NM_024565.8 → NP_078841.3  cyclin-J-like protein isoform a

      See identical proteins and their annotated locations for NP_078841.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC112191, BC013353, BC035871, BF111450
      Consensus CDS
      CCDS4350.2
      UniProtKB/Swiss-Prot
      Q6ZN43, Q8IV13, Q9H7W8
      Related
      ENSP00000377547.3, ENST00000393977.7
      Conserved Domains (2) summary
      pfam02984
      Location:193 → 295
      Cyclin_C; Cyclin, C-terminal domain
      cl00050
      Location:14 → 93
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RNA

    1. NR_131769.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112191, AK131381, AK294000, BF111450

    2. NR_177110.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112191

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      160249083..160339570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534646.4 → XP_011532948.1  cyclin-J-like protein isoform X5

      See identical proteins and their annotated locations for XP_011532948.1

      Conserved Domains (1) summary
      pfam02984
      Location:123 → 230
      Cyclin_C; Cyclin, C-terminal domain

    2. XM_017009847.2 → XP_016865336.2  cyclin-J-like protein isoform X3

    3. XM_006714917.5 → XP_006714980.1  cyclin-J-like protein isoform X1

      Conserved Domains (2) summary
      cd00043
      Location:35 → 90
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam02984
      Location:190 → 292
      Cyclin_C; Cyclin, C-terminal domain

    4. XM_047417702.1 → XP_047273658.1  cyclin-J-like protein isoform X4

    5. XM_047417704.1 → XP_047273660.1  cyclin-J-like protein isoform X7

    6. XM_011534647.4 → XP_011532949.1  cyclin-J-like protein isoform X6

      Conserved Domains (1) summary
      pfam02984
      Location:87 → 189
      Cyclin_C; Cyclin, C-terminal domain

    7. XM_047417701.1 → XP_047273657.1  cyclin-J-like protein isoform X2

      UniProtKB/TrEMBL
      E7EN43
      Related
      ENSP00000427960.1, ENST00000519673.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      160777639..160868099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353446.1 → XP_054209421.1  cyclin-J-like protein isoform X5

    2. XM_054353443.1 → XP_054209418.1  cyclin-J-like protein isoform X3

    3. XM_054353441.1 → XP_054209416.1  cyclin-J-like protein isoform X1

    4. XM_054353444.1 → XP_054209419.1  cyclin-J-like protein isoform X4

    5. XM_054353447.1 → XP_054209422.1  cyclin-J-like protein isoform X7

    6. XM_054353445.1 → XP_054209420.1  cyclin-J-like protein isoform X6

    7. XM_054353442.1 → XP_054209417.1  cyclin-J-like protein isoform X2

      UniProtKB/TrEMBL
      E7EN43
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IV13.3 GenPept UniProtKB/Swiss-Prot:Q8IV13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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