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    Polr3g polymerase (RNA) III (DNA directed) polypeptide G [ Mus musculus (house mouse) ]

    Gene ID: 67486, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr3gprovided by MGI
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide Gprovided by MGI
    Primary source
    MGI:MGI:1914736
    See related
    Ensembl:ENSMUSG00000035834 AllianceGenome:MGI:1914736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPC7; RPC32; 2310047G20Rik
    Summary
    Enables chromatin binding activity. Acts upstream of or within epithelial cell proliferation. Is active in nucleus. Is expressed in neocortex. Orthologous to human POLR3G (RNA polymerase III subunit G). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.2), CNS E11.5 (RPKM 4.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Polr3g in Genome Data Viewer
    Location:
    13 C3; 13 43.68 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (81821956..81859132, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (81673837..81711013, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32639 Neighboring gene adhesion G protein-coupled receptor V1 Neighboring gene STARR-seq mESC enhancer starr_35120 Neighboring gene STARR-seq mESC enhancer starr_35121 Neighboring gene STARR-seq mESC enhancer starr_35122 Neighboring gene STARR-positive B cell enhancer ABC_E7257 Neighboring gene STARR-seq mESC enhancer starr_35124 Neighboring gene STARR-seq mESC enhancer starr_35125 Neighboring gene STARR-seq mESC enhancer starr_35126 Neighboring gene STARR-seq mESC enhancer starr_35129 Neighboring gene STARR-seq mESC enhancer starr_35131 Neighboring gene STARR-positive B cell enhancer ABC_E11550 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 3 Neighboring gene metallo-beta-lactamase domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_35132 Neighboring gene STARR-positive B cell enhancer ABC_E604 Neighboring gene STARR-positive B cell enhancer ABC_E3088 Neighboring gene centrin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development. Wang X, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32576691, Free PMC Article
    2. A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells. Wong RC, et al. Stem Cells, 2011 Oct. PMID 21898682
    3. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. Wang Z, et al. Genes Dev, 1997 May 15. PMID 9171375
    4. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Molyneaux BJ, et al. Neuron, 2015 Jan 21. PMID 25556833, Free PMC Article
    5. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Renaud M, et al. Genome Res, 2014 Jan. PMID 24107381, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development.
      Title: Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development.
    2. POLR3G is absent in unfertilized oocytes and present predominately in the cytoplasm in fertilized zygotes and two cell embryos.
      Title: A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epithelial cell proliferation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC7
    Names
    DNA-directed RNA polymerase III subunit G
    RNA polymerase III subunit C7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081176.1 → NP_001074645.1  DNA-directed RNA polymerase III subunit RPC7

      See identical proteins and their annotated locations for NP_001074645.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154771
      Consensus CDS
      CCDS36738.1
      UniProtKB/Swiss-Prot
      Q6NXY9, Q8K0W5, Q9CV05
      Related
      ENSMUSP00000035289.6, ENSMUST00000048993.12
      Conserved Domains (1) summary
      pfam11705
      Location:1 → 220
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      81821956..81859132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026190.1: Suppressed sequence

      Description
      NM_026190.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXY9.1 GenPept UniProtKB/Swiss-Prot:Q6NXY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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